Sökning: "subclones"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet subclones.

1. 1. Chronic lymphocytic leukemia : Studies on cardiovascular disease, biomarkers and subclones

   Författare :Karin Larsson; Martin Höglund; Geir Tjønnfjord; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : Chronic lymphocytic leukemia; cardiovascular disease; population-based; biomarkers; subclones; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The treatment of Chronic lymphocytic leukemia (CLL) is rapidly changing, with targeted therapies, e.g. Bruton’s tyrosine kinase inhibitors (BTKi), entering the frontline and relapse setting. However, BTKis have significant adverse effects, most notably cardiovascular disease (CVD). LÄS MER

3. 2. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations

   Författare :Louise Pettersson; Lund Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AML; MRD; Measurable residual disease; NPM1; NPM1-mutation; NPM1 type A mutation; clonal evolution; clonal patterns; subclones; genetic evolution; qPCR; RQ-PCR; ddPCR; deep seq; deep sequencing; NGS; RT-qPCR; old; elderly; MFC; flow cytometry;

   Sammanfattning : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. LÄS MER

4. 3. Diversity and persistence of Helicobacter pylori

   Författare :Annelie Lundin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Helicobacter pylori; genomic diversity; cag pathogenicity island; Nudix hydrolase;

   Sammanfattning : Helicobacter pylori is an exceptionally diverse bacterial species, and every infected individual harbors a unique strain, apart from the strain concordance found in some families. The infection is usually acquired during childhood and once established, persists for life unless treated with antibiotics. LÄS MER

5. 4. TP53 mutations in myelodysplastic syndromes with deletion of 5q

   Författare :Leonie Saft; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia(s) and increased risk of progression to acute myeloid leukemia (AML). International Prognostic Scoring system (IPSS) Low- or Intermediate (INT)-1 risk MDS with a deletion of 5q (del5q) were considered to have an indolent course and a low risk for progression to AML as compared to other MDS subtypes. LÄS MER

7. 5. Aiway Mucins: experimental models for studies of secretions

   Författare :Naila Svitacheva; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystic fibrosis; bovine trachea; radiolabelling; cell line; primary cell culture; organ culture; mucus; mucin; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Mucins are essential components of the mucosal barrier. The complexity of the airway mucosal barrier is reflected in the lack of specific treatments to block mucin hypersecretion associated with several respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. LÄS MER