Sökning: "structural proteomics"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden structural proteomics.

  1. 1. Machine Learning methods in shotgun proteomics

    Författare :Patrick Truong; Lukas Käll; Peter Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry protein summarization Bayesian hierarchical modelling label-free quantification data-independent acquisition mass spectrometry; benchmark mathematical methods; transformers; computational proteomics; proteomics; bioinformatics; bert; ms2 intensity; probabilistic modelling; Biotechnology; Bioteknologi;

    Sammanfattning : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. LÄS MER

  3. 2. Global Proteome Survey -Transforming antibody-based affinity proteomics into a global discovery platform

    Författare :Niclas Olsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity proteomics; recombinant antibodies; Proteomics; mass spectrometry; proteome profiling; breast cancer; antibody specificity;

    Sammanfattning : Proteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurements. LÄS MER

  4. 3. Sequence- and structure guided engineering of proteins and enzymes for biotechnology and health applications

    Författare :Karen Schriever; Per-Olof Syrén; Elton P. Hudson; Eric A. Gaucher; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein engineering; enzymology; ancestral sequence reconstruction; antigen engineering; structural biology; terpene cyclases; enzyme thermodynamics; biocatalysis; phosphatases; allosteric regulation; Biotechnology; Bioteknologi;

    Sammanfattning : Proteins are highly diverse and sophisticated biomolecules that represent a cornerstone of biological structure and function and have been exploited in man-made applications for thousands of years. Those proteins that facilitate chemical reactions at physiologically relevant time-scales are referred to as enzymes. LÄS MER

  5. 4. Functional proteomics of protein phosphorylation in algal photosynthetic membranes

    Författare :Maria Turkina; Peter Strålfors; Göran Samuelsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein phosphorylation; mass spectrometry; photosynthesis; proteomics; Biochemistry; Biokemi;

    Sammanfattning : Plants, green algae and cyanobacteria perform photosynthetic conversion of sunlight into chemical energy in the permanently changing natural environment. For successful survival and growth photosynthetic organisms have developed complex sensing and signaling acclimation mechanisms. LÄS MER

  7. 5. Separation Methods in Membrane Proteomics -Integration of Aqueous Two-Phase Partitioning for Enrichment and Pre-Fractionation

    Författare :Henrik Everberg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Proteins; metabolism; Biokemi; Metabolism; Biochemistry; Aqueous two-phase partitioning; enzymology; Proteiner; enzymologi; Proteomics;

    Sammanfattning : The study of the protein complement of a genome is called proteomics. Proteomics can be defined as identification, quantification and characterization of a total set of proteins expressed at different time-points or under different cellular states to provide global information about biological processes. LÄS MER