Sökning: "structural modeling"

Visar resultat 21 - 25 av 387 avhandlingar innehållade orden structural modeling.

1. 21. Structural / functional studies on human alkaline phosphatases

   Författare :Alexey Kozlenkov; Jose-Luis Millan; Hans Jörnvall; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; mutagenesis; enzyme kinetics; computer modeling; crystallography; natural substrates; uncompetitive inhibition; isozymes; gene families; Biomedicin; Microbiology; Mikrobiologi; medicinsk genetik; Medical Genetics;

   Sammanfattning : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. LÄS MER

3. 22. Using direct manipulation for real-time structural design exploration

   Författare :Daniel Åkesson; Byggnadsmekanik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Interactive structural analysis; Very direct manipulation; Interactive structural form finding;

   Sammanfattning : Before a new structure can be built, it must be designed. This design phase is a very important step in the building process. The total cost of the structure and its structural performance are largely dependent on the structural design process. The impact of decisions on the design process is initially high and declines as the design matures. LÄS MER

4. 23. Effective schools in a segregated landscape : Studies of academic achievement and psychological well-being among adolescents in Sweden

   Författare :Maria Granvik Saminathen; Bitte Modin; Sara Brolin Låftman; Stephanie Plenty; Torbjørn Torsheim; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psychological health; adolescence; segregation; educational equity; school; academic achievement; structural equation modeling; multilevel modeling; folkhälsovetenskap; Public Health Sciences;

   Sammanfattning : Equitable educational opportunities necessitate equitable access to a favourable academic and social school environment. This thesis aims to explore the role of the school as an educational and social arena for the academic achievement and psychological well-being of lower secondary school students in Sweden. LÄS MER

5. 24. Unsupervised Learning of Biomolecular Dynamics with Multi-Modal Data

   Författare :Christopher Kolloff; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biomolecular dynamics; data-driven modeling; integrative structural biology; generative modeling; multi- modal machine learning; statistical mechanics; augmented Markov models;

   Sammanfattning : The functioning of cells critically depends on the dynamics of biomolecular systems, such as proteins or nucleic acids. Biophysical experiments as well as Molecular Dynamics (MD) simulations are the primary techniques to model and understand the kinetics and thermodynamics of biomolecules. LÄS MER

7. 25. Structural Analysis of Existing RC Bridge Deck Slabs Structural Analysis of Existing RC Bridge Deck Slabs

   Författare :Jiangpeng Shu; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; load-carrying capacity; assessment; Reinforced concrete RC bridge deck slabs; structural behaviour; Finite element FE analyses;

   Sammanfattning : Due to ageing of the bridge stock, continuously increasing load requirements, the need for assessing existing bridges is becoming increasingly important. Reinforced concrete (RC) bridge deck slabs are among the most critical parts to the load carrying capacity of bridges. LÄS MER