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Visar resultat 1 - 5 av 387 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Structural modeling of membrane transporter proteins

   Författare :Jonas Almqvist; Sven Hovmöller; David van der Spoel; Stockholms universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; membrane protein structure; membrane protein crystallography; membrane protein structure modelling; Structural biochemistry; Strukturbiokemi; strukturkemi; Structural Chemistry;

   Sammanfattning : A fundamental process of all living organisms - the transport of molecules across cellular membranes through membrane transport proteins - is investigated.After a brief review of general properties of biological membranes follows a recollection of the major methods of membrane transport that Nature utilizes (Chapter 1). LÄS MER

3. 2. Crustal architecture of the Kiruna mining district : Structural framework, geological modeling, and physical rock property distribution

   Författare :Ervin Csaba Veress; Tobias Bauer; Stefan Luth; Luleå tekniska universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kiruna mining district; geological modeling; structural framework; common earth modeling; petrophysical characterization; mineral exploration; iron oxide-apatite; Ore Geology; Malmgeologi;

   Sammanfattning : Rapid technological advancements and growing environmental consciousness created a shifting dynamic of metal demand within the context of contemporary global challenges. The metals play a pivotal role in this transformation and remarkable surge in demand is expected. LÄS MER

4. 3. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties

   Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

5. 4. Imaging and modeling the cardiovascular system

   Författare :Elira Maksuti; Michael Broomé; Anna Bjällmark; Matilda Larsson; Martin Ugander; Patrick Segers; KTH; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Cardiac pumping; diastolic function; hemodynamics; modeling; simulation; arterial stiffness; ultrasound; shear wave elastography.; Medical Technology; Medicinsk teknologi; Cardiac pumping;

   Sammanfattning : Understanding cardiac pumping function is crucial to guiding diagnosis, predicting outcomes of interventions, and designing medical devices that interact with the cardiovascular system.  Computer simulations of hemodynamics can show how the complex cardiovascular system is influenced by changes in single or multiple parameters and can be used to test clinical hypotheses. LÄS MER

7. 5. Major Intrinsic Proteins - Structure, function, interactions

   Författare :ANDREAS KIRSCHT; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aquaporin; membrane proteins; crystallography; stopped-flow; molecular dynamics; structure modeling;

   Sammanfattning : Major intrinsic proteins, also referred to as aquaporins (AQPs) are localized in membranes of all domains of life to increase the permeability to water or other small, polar molecules. Several monophyletic groups can be discerned in this large and divergent protein superfamily. LÄS MER