Sökning: "structural mechanism"

Visar resultat 11 - 15 av 694 avhandlingar innehållade orden structural mechanism.

  1. 11. Water transport regulation: Biochemical and structural analyses of eukaryotic aquaporins

    Författare :Anna Maria Nyblom; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; regulation; aquaporins; function; structure; membrane proteins;

    Sammanfattning : Water is essential for all living beings. Aquaporins are water channel proteins embedded in the membranes of cells. These macromolecules are found in all kingdoms of life and they control water homeostasis by diverse regulation mechanisms. LÄS MER

  3. 12. The structural basis for the catalytic specificity of manganese lipoxygenases : 3D structure analysis of the lipoxygenase of Magnaporthe oryzae

    Författare :Anneli Wennman; Ernst H. Oliw; Marcia Newcomer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; oxylipin; lipoxygenase; crystal structure; crystallography; HPLC; mass spectrometry; yeast; site-directed mutagenesis; fungi; Biochemical Pharmacology; Biokemisk farmakologi;

    Sammanfattning : Lipoxygenases (LOX) catalyze regio- and stereospecific oxygenation of polyunsaturated fatty acids to hydroperoxides. These hydroperoxides are further metabolized to leukotrienes and lipoxins in mammals, and are involved in asthma and inflammation. LOX of animals and plants contain iron as catalytic metal (FeLOX). LÄS MER

  4. 13. Sequence- and structure guided engineering of proteins and enzymes for biotechnology and health applications

    Författare :Karen Schriever; Per-Olof Syrén; Elton P. Hudson; Eric A. Gaucher; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein engineering; enzymology; ancestral sequence reconstruction; antigen engineering; structural biology; terpene cyclases; enzyme thermodynamics; biocatalysis; phosphatases; allosteric regulation; Biotechnology; Bioteknologi;

    Sammanfattning : Proteins are highly diverse and sophisticated biomolecules that represent a cornerstone of biological structure and function and have been exploited in man-made applications for thousands of years. Those proteins that facilitate chemical reactions at physiologically relevant time-scales are referred to as enzymes. LÄS MER

  5. 14. Dissecting function and catalytic mechanism of fungal lytic polysaccharide monooxygenases

    Författare :Bing Liu; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Fungi use a complex and well-orchestrated enzyme machinery to degrade lignocellulose biomass, in which both hydrolytic and redox enzymes are involved. Lytic polysaccharide monoxygenases (LPMOs) are copper-dependent enzymes that cleave bonds in polysaccharides using oxidative mechanisms. LÄS MER

  7. 15. Structural investigation of human mitochondrial translation and off-target antibiotic binding

    Författare :Vivek Singh; Alexey Amunts; Yaser Hashem; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial translation; mitoribosome; electron cryo-microscopy; LRPPRC-SLIRP; antibiotics; streptomycin; Biophysics; biofysik;

    Sammanfattning : Human mitochondrial translation machinery has evolved to translate 13 mitochondrial mRNAs encoding components of the oxidative phosphorylation pathway responsible for ATP production. The structural basis of human mitochondrial translation is distinct from the canonical bacterial and cytosolic translation systems. LÄS MER