Sökning: "structural knowledge"

Visar resultat 1 - 5 av 966 avhandlingar innehållade orden structural knowledge.

  1. 1. Structural studies of the surface adhesin SspB from Streptococcus gordonii

    Författare :Nina Forsgren; Karina Persson; Inger Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus gordonii; X-ray crystallography; surface adhesin; dental plaque; structural biology; Structural biology; Strukturbiologi; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Sammanfattning : Surface proteins on microorganisms that build up the oral biofilm are key players in the formation of the biofilm. Antigen I/II proteins are surface adhesins found on virtually all oral streptococci and share a conserved multi-domain architecture. These adhesins bind surface components on other bacteria and on host cells. LÄS MER

  3. 2. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Författare :Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Sammanfattning : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). LÄS MER

  4. 3. Dynamic Knowledge Integration : A field study of an Information Systems Development Project

    Författare :Linnéa Wahlstedt; Lars Lindkvist; Tim Brady; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Knowledge integration process; collective heuristic; development projects; problem-solving; knowledge diversity; field study; Kunskapsintegrationsprocess; kollektiv heuristik; utvecklingsprojekt; problemlösning; kunskapsbaserade olikheter; fältstudie;

    Sammanfattning : Current research on knowledge integration offers valuable structural analyses of factors that influence knowledge integration, performance outcomes, and knowledge integration mechanisms. Less attention has been paid to how knowledge integration is carried out over time in cross-functional development projects. LÄS MER

  5. 4. Structural Studies of Flexible Biomolecules and a DNA-binding Protein

    Författare :Tariq Massad; Pål Stenmark; Cheryl Arrowsmith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Maximum entropy; motilin; DNA-binding proteins; Karplus equation; disaccaride; direct repeats; Structural biology; Strukturbiologi; Biophysics; biofysik;

    Sammanfattning : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. LÄS MER

  7. 5. Structural Violence as a Constraint to African Policy Formation in the 1990s : Respositioning Education in International Relations

    Författare :Catherine A Odora Hoppers; Birgit Brock-Utne; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Structural violence; policy formation; power relations; aid; discourses; geo-politics; education; knowledge; neo-liberalism; Structural Adjustment Programmes; reflexivity; transdisciplinarity; Public Policy Dialogue.; internationell pedagogik; International Education;

    Sammanfattning : This study is a meta-analysis of the manner in which global relations impact on national level policy spaces and policy formation. As the International Financial Institutions tighten their grip through the Structural Adjustment Programmes over African countries, and donors steadily shift their ground and push conditionality beyond economic policy into institutional arrangements, the issue of political sovereignty of African countries, and of indirect rule through aid becomes a key concern. LÄS MER