Sökning: "structural evolution"

Visar resultat 1 - 5 av 344 avhandlingar innehållade orden structural evolution.

  1. 1. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

    Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

    Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

  3. 2. Ribosomal RNA Modification Enzymes : Structural and functional studies of two methyltransferases for 23S rRNA modification in Escherichia coli

    Författare :Avinash S. Punekar; Maria Selmer; Martino Bolognesi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome biogenesis; ribosome assembly; ribosomal RNA; peptidyltransferase center; domain V; post-transcriptional modification; methyltransferases; S-adenosyl-methionine; RlmM; Cm2498; RlmJ; m6A2030; X-ray crystallography; substrate recognition; substrate specificity; catalytic mechanism; evolution; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry;

    Sammanfattning : Escherichia coli ribosomal RNA (rRNA) is post-transcriptionally modified by site-specific enzymes. The role of most modifications is not known and little is known about how these enzymes recognize their target substrates. LÄS MER

  4. 3. Complex Networks : Structure, Function , Evolution

    Författare :Ala Trusina; Petter Minnhagen; Kim Sneppen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Complex systems; network topology; evolution; information spread; Condensed matter physics; Kondenserade materiens fysik;

    Sammanfattning : A complex system is a system for which the statement "the whole is greater than the sum of its parts" holds. A network can be viewed as a backbone of a complex system. LÄS MER

  5. 4. Structural and functional properties of transthyretin

    Författare :Anders Karlsson; A. Elisabeth Sauer-Eriksson; Salam Al-Karadaghi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Amyloidosis; X-ray crystallography; Protein structure; Protein; Structural biology; Strukturbiologi;

    Sammanfattning : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. LÄS MER

  7. 5. Evolution of Plants : a mathematical perspective

    Författare :Magnus Lindh; Åke Brännström; Jacob Johansson; Mats G Larson; Lennart Persson; Claus Rüffler; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; plants; mathematics; optimization; optimal control; adaptive dynamics; flowering; seasons; tree crown; drought; taproot; trade-off; strategy; trait; ESS; NPP; LAI; Red Queen; Mathematics; matematik;

    Sammanfattning : The Earth harbors around 300 000 plant species. The rich and complex environment provided by plants is considered a key factor for the extraordinary diversity of the terrestrial fauna by, for example, providing food and shelter. LÄS MER