Sökning: "structural alteration"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden structural alteration.

1. 1. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

   Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

   Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

3. 2. Crustal architecture of the Kiruna mining district : Structural framework, geological modeling, and physical rock property distribution

   Författare :Ervin Csaba Veress; Tobias Bauer; Stefan Luth; Luleå tekniska universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kiruna mining district; geological modeling; structural framework; common earth modeling; petrophysical characterization; mineral exploration; iron oxide-apatite; Ore Geology; Malmgeologi;

   Sammanfattning : Rapid technological advancements and growing environmental consciousness created a shifting dynamic of metal demand within the context of contemporary global challenges. The metals play a pivotal role in this transformation and remarkable surge in demand is expected. LÄS MER

4. 3. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

   Författare :Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER

5. 4. Paleoproterozoic deformation in the Kiruna‑Gällivare area in northern Norrbotten, Sweden : Setting, character, age, and control of iron oxide-apatite deposits

   Författare :Joel Andersson; Tobias Bauer; Olof Martinsson; Nicholas Oliver; Luleå tekniska universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kiruna; Gällivare; structural geology; Paleoproterozoic; deformation; Malmgeologi; Ore Geology;

   Sammanfattning : This thesis covers the structural evolution of the Kiruna‑Gällivare area in the northern Norrbotten ore province, Sweden. The study area hosts several economically significant iron oxide-apatite (IOA) deposits and includes the type locality for this ore type. LÄS MER

7. 5. Upgrading concrete bridges : post-tensioning for higher loads

   Författare :Jonny Nilimaa; Mohammad Al-Emrani; Luleå tekniska universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Concrete; Bridges; Upgrading; Strengthening; Shear; Field testing; Post-tensioning; Prestressing; Structural Engineering; Konstruktionsteknik;

   Sammanfattning : There are a great number of old structures around the world, some of which were designed for completely different purposes than in their current application. Swedish railway bridges were for example only designed for maximum axle loads of 200 kN in the beginning of the 20th century, while the highest axle loads of today are twice as high. LÄS MER