Sökning: "structural alteration"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden structural alteration.

  1. 1. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

    Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

    Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

  2. 2. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

    Författare :Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER

  3. 3. Concrete Bridges : Improved Load Capacity

    Författare :Jonny Nilimaa; Luleå tekniska universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Structural Engineering; Konstruktionsteknik;

    Sammanfattning : There are many beautiful old structures around the world, some of which were designed for completely different purposes than their current applications. For example, Swedish railway bridges were only designed to carry axle loads up to 200 kN in the beginning of the 20th century, while modern loads can be twice as high. LÄS MER

  4. 4. Upgrading concrete bridges : post-tensioning for higher loads

    Författare :Jonny Nilimaa; Luleå tekniska universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Civil engineering and architecture - Building engineering; Concrete; Bridges; Upgrading; Strengthening; Shear; Field testing; Post-tensioning; Prestressing; Samhällsbyggnadsteknik och arkitektur - Byggnadsteknik; Structural Engineering; Konstruktionsteknik;

    Sammanfattning : There are a great number of old structures around the world, some of which were designed for completely different purposes than in their current application. Swedish railway bridges were for example only designed for maximum axle loads of 200 kN in the beginning of the 20th century, while the highest axle loads of today are twice as high. LÄS MER

  5. 5. Constipation : symptoms and findings in relation to structural and functional abnormalities

    Författare :Abdulhakim Glia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; constipation; defecation; electromyography; gastrointestinal motility; immunchistochernistry; intestinal pseudo-obstruction; physiopathology; quality of life; transit time;

    Sammanfattning : The aim of this study was to increase the knowledge about functional constipation with special reference to symptoms analysis, laboratory investigations and histopathology findings. 155 consecutive patients with intractable constipation underwent anorectal manometry, electromyography (EMG), balloon expulsion test, colonic transit time, and defecography. LÄS MER