Sökning: "structural alteration"
Visar resultat 1 - 5 av 34 avhandlingar innehållade orden structural alteration.
Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER
Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER
Sammanfattning : There are many beautiful old structures around the world, some of which were designed for completely different purposes than their current applications. For example, Swedish railway bridges were only designed to carry axle loads up to 200 kN in the beginning of the 20th century, while modern loads can be twice as high. LÄS MER
Sammanfattning : There are a great number of old structures around the world, some of which were designed for completely different purposes than in their current application. Swedish railway bridges were for example only designed for maximum axle loads of 200 kN in the beginning of the 20th century, while the highest axle loads of today are twice as high. LÄS MER
Sammanfattning : The aim of this study was to increase the knowledge about functional constipation with special reference to symptoms analysis, laboratory investigations and histopathology findings. 155 consecutive patients with intractable constipation underwent anorectal manometry, electromyography (EMG), balloon expulsion test, colonic transit time, and defecography. LÄS MER