Sökning: "striatum"

Visar resultat 16 - 20 av 256 avhandlingar innehållade ordet striatum.

1. 16. Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat

   Författare :Amir Lotfi Moghaddam; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; withdrawal; nicotine; amphetamine; striatum; GABA; glutamate; dopamine; sensitization; locomotor activity;

   Sammanfattning : Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development of habitual and compulsive behavior, namely subregions of striatum in the rat. LÄS MER

3. 17. Motion and Emotion : Functional In Vivo Analyses of the Mouse Basal Ganglia

   Författare :Emma Arvidsson; Åsa Wallén-Mackenzie; Cecilia Flores; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopamine; Basal Ganglia; Reward System; In Vivo Chronoamperometry; Optogenetics; Deep Brain Stimulation; Parkinson’s Disease; Addiction; Glutamate; Vesicular Glutamate Transporter; VGLUT2; Sex; Age; Subthalamic Nucleus; Striatum; Nucleus Accumbens; Ventral Tegmental Area;

   Sammanfattning : A major challenge in the field of neuroscience is to link behavior with specific neuronal circuitries and cellular events. One way of facing this challenge is to identify unique cellular markers and thus have the ability to, through various mouse genetics tools, mimic, manipulate and control various aspects of neuronal activity to decipher their correlation to behavior. LÄS MER

4. 18. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

   Författare :Charlotta Skogh; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

   Sammanfattning : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. LÄS MER

5. 19. Striatal pathways in dyskinesia and dystonia

   Författare :Laura Andreoli; Basala gangliernas patofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Dystonia; L-DOPA-induced dyskinesia; DREADD; Mouse model; Dopamine; dopamine receptor;

   Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER

7. 20. Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats

   Författare :Klara Danielsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; striatum; addiction; schizophrenia;

   Sammanfattning : The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral striatum are substance use disorder, and negative symptoms in schizophrenia, both of which are difficult to treat. LÄS MER