Sökning: "striatal plasticity"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden striatal plasticity.

  1. 16. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

    Författare :Daniella Rylander; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

    Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER

  3. 17. Information processing in the Striatum : a computational study

    Författare :Johannes Hjorth; Jeanette Hellgren Kotaleski; Anders Lansner; Kim Blackwell; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; striatum; fast spiking interneuron; gap junctions; synchronisation; up-state detection; CaMKII; mathematical modelling; Neuroscience; Neurovetenskap;

    Sammanfattning : The basal ganglia form an important structure centrally placed in the brain. They receive input from motor, associative and limbic areas, and produce output mainly to the thalamus and the brain stem. The basal ganglia have been implied in cognitive and motor functions. LÄS MER

  4. 18. Inflammation and Stem Cell Therapy for Stroke

    Författare :Ruimin Ge; Lund Neurologi; []
    Nyckelord :;

    Sammanfattning : Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. LÄS MER

  5. 19. Computational Dissection of the Basal Ganglia : functions and dynamics in health and disease

    Författare :Mikael Lindahl; Jeanette Hällgren Kotaleski; Mark Humphries; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computer Science; Datalogi;

    Sammanfattning : The basal ganglia (BG), a group of nuclei in the forebrain of all vertebrates, are important for behavioral selection. BG receive contextual input from most cortical areas as well as from parts of the thalamus, and provide output to brain systems that are involved in the generation of behavior, i.e. the thalamus and the brain stem. LÄS MER

  7. 20. Bridging the gap between lipid dyshomeostasis and brain disorders : role of prosaposin and progranulin

    Författare :Yachao He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Brain tissue is the second-highest lipid-containing tissue after adipose in the human body. Lipid homeostasis maintenance requires the coordination of multiple cellular organelles. Pathogenesis of brain disorders, especially Parkinson’s disease (PD), usually involves different dysfunctional pathways that intimately link to lipid homeostasis. LÄS MER