Sökning: "striatal plasticity"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden striatal plasticity.

  1. 1. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity

    Författare :Anu G. Nair; Jeanette Hellgren Kotaleski; Omar Gutierrez-Arenas; Upinder S. Bhalla; Pierre Vincent; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Striatal synaptic plasticity; LTP; Dopamine; Acetylcholine; Synergy; Medium spiny neurons; MSNs;

    Sammanfattning : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. LÄS MER

  2. 2. Striatal glutamatergic neurotransmission and plasticity in Parkinson's disease and aging

    Författare :Mona Nouhi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Parkinson's disease (PD) is a devastating neurodegenerative disorder with aging as the main risk factor. PD is characterized by severe movement disturbances but is also associated with non-motor symptoms. LÄS MER

  3. 3. Transcriptional dysregulation in L-DOPA-induced dyskinesia

    Författare :Malin Andersson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; neurofysiologi; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; CREB; jun; fos; immediate early genes; prodynorphin; striatal plasticity; Parkinson s disease; dyskinesia; Klinisk genetik;

    Sammanfattning : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. LÄS MER

  4. 4. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia

    Författare :Tim Fieblinger; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Parkinson’s disease; L-DOPA-induced dyskinesia; ERK1 2; mGluR5; homeostatic plasticity; SPN; 2‑Photon microscopy;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. LÄS MER

  5. 5. Synaptic transmission and synaptic plasticity in the mouse striatum

    Författare :Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. LÄS MER