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  1. 1. Recurrent Streptococcal Pharyngotonsillitis Studies on etiology and treatment

    Författare :Arne Orrling; Lund näs- och halssjukdomar Öron-; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; auditive system and speech; Otorinolaryngologi; Infektioner; Otorhinolaryngology; Infections; Clindamycin.; Penicillin tolerance; Tonsillar surface fluid; treatment failure; Group A streptococci; hörsel- och talorganen; audiologi; audiology; Recurrent streptococcal pharyngotonsillitis;

    Sammanfattning : In acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of failures remains largely elusive. LÄS MER

  2. 2. Streptococcal M protein and human C4BP

    Författare :Jenny J Persson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; Medicin människa och djur ; Medicine human and vertebrates ; human C4BP; M protein; antigenic variation; sequence variability; Streptococcus pyogenes; innate immunity;

    Sammanfattning : Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. LÄS MER

  3. 3. Group B streptococcal infections in neonates : Clinical and pathogenic aspects

    Författare :Jan Källman; Leif Gothefors; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Clinical and pathogenic aspects of Group B streptococci (GBS), as a major pathogen responsible of invasive disease in newborn infants, were investigated.Cases of neonatal septicaemia during 1981-1994 were studied at Orebro Medical Centre Hospital. 132 children ful1filled laboratory and clinical criteria for neonatal septicaemia. LÄS MER

  4. 4. Interactions between streptococcal M proteins and human plasma proteins

    Författare :Charlotta Sandin; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; innate immunity; Streptococcus pyogenes; phagocytosis resistance;

    Sammanfattning : Streptococcus pyogenes is a common human pathogen, which causes a variety of diseases. A major virulence factor of S. pyogenes is the surface-associated M protein, which mediates resistance to phagocytosis. Several studies indicate that M proteins inhibit complement deposition and thereby phagocytosis. LÄS MER

  5. 5. Microbiologic diagnostic tests when asymptomatic carriers are present. Aspects of the use of conventional throat and nasopharyngeal culture as examples

    Författare :Ronny K Gunnarsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carriage; respiratory tract infections; predictive value of tests; epidemiology; decision making; streptococcal infections; Streptococcus pyogenes; tonsillitis;

    Sammanfattning : Carriers of potentially pathogenic bacteria simultaneously ill from a viral infection complicatethe diagnostic procedure in respiratory tract infections. The present statistical methodsavailable to evaluate common diagnostic tests either ignore the phenomenon of carriers orprovide test characteristics that are difficult to apply in clinical decision making. LÄS MER