Sökning: "stratum corneum"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden stratum corneum.

  1. 1. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Författare :Sebastian Björklund; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Sammanfattning : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. LÄS MER

  3. 2. Self-Assembly in Lipid-Protein Systems : Lung Surfactant, Stratum Corneum and Model Membranes

    Författare :Jenny Andersson; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lipid self-assembly; lung surfactant; stratum corneum; dehydrin; cholesterol; osmolytes; urea; TMAO; ssNMR; cSAXS;

    Sammanfattning : This thesis explores lipid self-assembly and aims to give a broad picture of self-assembly structures in simple and complex lipid-protein systems. The systems studied are lung surfactant, stratum corneum and simple model membranes. The lung surfactant mixture lines the alveolus in our lungs and stabilises the air- tissue interface. LÄS MER

  4. 3. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Författare :Quoc Dat Pham; Fysikalisk kemi; []
    Nyckelord :stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Sammanfattning : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. LÄS MER

  5. 4. Steady-State Diffusion in Complex Amphiphilic Films

    Författare :Christoffer Åberg; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; film formation; lung surfactant; skin surface pH; stratum corneum; responding membrane; diffusive transport; phase transition;

    Sammanfattning : The relation between structure and diffusive transport at steady-state is investigated theoretically for amphiphilic systems. Amphiphilic systems typically show a large response to moderate changes in control parameters, such as temperature, osmotic pressure, and the presence of cosolvents and cosolutes. LÄS MER

  7. 5. Lipid bilayers versus monolayers- Sponge phases and skin lipid domains

    Författare :Katarina Ekelund; Livsmedelsteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; fatty acids; Langmuir-Blodgett films; AFM; domains; stratum corneum; bilayer curvature; lipids; glycerol monooleate; phase behaviour; sponge phase; L3 phase; Livsmedelsteknik; cholesterol; Food and drink technology;

    Sammanfattning : The L3, or sponge, phase is a thermodynamically stable isotropic liquid consisting of a surfactant membrane in aqueous solution. A solvent induced L3 phase is shown in systems of solvent, monoolein and water. LÄS MER