Sökning: "steroid hormones"

Visar resultat 11 - 15 av 120 avhandlingar innehållade orden steroid hormones.

1. 11. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

   Författare :Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. LÄS MER

3. 12. Analytical method development for ultra-trace determination of human pharmaceuticals in aqueous samples. Assessing the performance of a sewage treatment plant

   Författare :Saioa Zorita; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecularly imprinted solid-phase extraction; Sample preparation; solid-phase extraction; membrane extraction; human pharmaceuticals; sewage treatment plant; steroid hormones;

   Sammanfattning : Research focus in environmental pollution has recently been extended from more classical environmental pollutants such as PCBs or pesticides to pharmaceuticals and steroid hormones, which are designed to be biologically active and enter the environment primarily through regular domestic use. Consequently, it is important to monitor these substances concentrations in the effluents of sewage treatment plants (STPs) and in the environment in order to evaluate their associated risks. LÄS MER

4. 13. Development of GC-HRMS procedures for determination of naturally occuring polar compounds in various environmental applications

   Författare :Bodil Widell; Dag Broman; Caroline Leck; Joan Grimalt; Stockholms universitet; []
   Nyckelord :GC-HRMS; steroid hormones; amino acids; perch; size-resolved aerosol; Arctic; NATURAL SCIENCES; NATURVETENSKAP; Applied Environmental Science; tillämpad miljövetenskap;

   Sammanfattning : The overall objectives of this dissertation were to gain further understanding of the two following environmentally significant issues: (i) Determination of natural steroid hormones in blood plasma from perch (Perca fluviatilis) during a reproductive cycle and to evaluate the possibility of using the steroid composition as a biomarker for early signs of endocrine disruptive effects. (ii) Determination of dissolved free amino acids in size resolved airborne particles collected over the Arctic pack ice area (>80°N) in summer and to study their overall relationship with the ocean surface microlayer as a potential source. LÄS MER

5. 14. Register-based studies of sex steroid hormones and psychiatric disorders

   Författare :Vide Gotby; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The focus of this thesis is the interplay between sex steroid hormones, psychiatric- and neurodevelopmental disorders and adverse behavioral outcomes. Sex steroid hormones are mostly known for their role in sexual differentiation and reproduction, but have been suggested to be involved the etiology of several psychiatric disorders and in adverse behaviors that show prominent sex differences in prevalence. LÄS MER

7. 15. Mass Spectrometric Applications for Diagnosing Metabolic and Endocrine Diseases

   Författare :Mark M. Kushnir; Jonas Bergquist; Alan L Rockwood; David Herold; Uppsala universitet; []
   Nyckelord :Analytical chemistry; biomarker; liquid chromatography; tandem mass spectrometry; LC-MS MS; sample preparation; isomers; steroid hormones; congenital adrenal hyperplasia; polycystic ovary syndrome; Analytisk kemi;

   Sammanfattning : Disease-specific compounds (biomarkers) are analyzed in clinical laboratories to assist with diagnosing diseases. This thesis describes development and validation of liquid chromatography tandem mass spectrometry (LC-MS/MS) based tests for diagnosing a diverse group of endocrine and metabolic diseases. LÄS MER