Sökning: "stereoisomer"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet stereoisomer.
1. Chiral building blocks for synthesis of pine sawfly sex pheromones Enantioselective Lipase Catalysed Acylations and Esterifications of Primary Alcohols and Acids and Synthesis of the Sex Pheromone of the Pine Sawfly Microdiprion pallipes
Sammanfattning : This thesis describes the development of new methods for thepreparation of enantiomerically pure methyl branched alkylcompounds and their use as building blocks in the synthesis ofstereoisomerically pure pheromones of pine sawflies.The high regioselectivity, enantioselectivity and activityof lipases in organic solvent in conjunction withenvironmentally compatible reaction conditions have madelipase-catalysed synthesis an attractive alternative toconventional synthetic methods in organic chemistry. LÄS MER
2. Introducing weak affinity chromatography to drug discovery with focus on fragment screening
Sammanfattning : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. LÄS MER
3. Asymmetric 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides, Thiocarbonyl Ylides, and Nitrones
Sammanfattning : This thesis describes the development of methods for thepreparation of chiral non-racemic substituted pyrrolidines,tetrahydrothiophenes, and isoxazolidines. This has beenaccomplished by using asymmetric intermolecular 1,3-dipolarcycloaddition reactions of azomethine ylides, thiocarbonylylides and nitrones, respectively, with variousdipolarophiles. LÄS MER
4. Palladium(II)-catalyzed 1,4-oxidations of 1,3-dienes : Development of an asymmetric version and synthetic applications
Sammanfattning : In this thesis the development of an asymmetric version and synthetic applications of the Pd(II)-catalyzed 1,4-oxidation of conjugated dienes are described. The thesis is divided into four parts:(i) The first part concerns the design and synthesis of chiral p-benzoquinones as ligands in the Pd(II)-catalyzed 1,4-diacetoxylation. LÄS MER
5. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis
Sammanfattning : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. LÄS MER
