Sökning: "stem cell transplantation"

Visar resultat 16 - 20 av 335 avhandlingar innehållade orden stem cell transplantation.

1. 16. Potential Hazards for Haematopoietic Stem Cell Donors

   Författare :Simon Pahnke; Hans Hägglund; Gunnar Larfors; Nina Worel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell donor; stem cell transplantation; cancer; haematology; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The aim of this thesis has been to increase our knowledge about the allogeneic stem cell donation procedure and the associated risks for stem cell donors.  In a first study (paper I), we described the donation procedure and short-term side effects of 1957 donors included in the Nordic Register of Haematopoietic Stem Cell Donors. LÄS MER

3. 17. Regulation of Hematopoietic Stem and Progenitor Cells by Bone Marrow Niche Components

   Författare :Hong Qian; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; Hematologi; extracellular fluids; Haematology; bone marrow; Hematopoiesis; extracellulära vätskor;

   Sammanfattning : Throughout the lifespan of an individual, enormous numbers of mature blood cells are generated by hematopoietic stem cells (HSCs) in the bone marrow (BM). The HSC is a cell that can self-renew to maintain the HSC pool and differentiate into all types of mature blood cells. LÄS MER

4. 18. Investigations of Hematopoietic Stem Cells and Their Age-Associated Alterations

   Författare :Alexandra Rundberg Nilsson; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; Aging; Serial transplantation; Self-renewal; Flow cytometry; Gene expression;

   Sammanfattning : The hematopoietic stem cell (HSC) has and continues to be extensively investigated, and represents by far the most studied somatic stem cell. Development of various experimental technologies, including fluorescence activated cell sorting (FACS), have been crucial for research advancements within the hematopoietic field. LÄS MER

5. 19. Molecular specification of expanded forebrain neural stem and progenitor cells

   Författare :Malin Parmar; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; teratology; ontogeny; embryology human ; Development biology; developmental control genes; in vitro expansion; transplantation; precursor cell; stem cells; progenitor cell; human; mouse; Utvecklingsbiologi; teratologi; embryologi människa ;

   Sammanfattning : The molecular specification of neural precursor cells has been suggested to be a progressive process, with a transition from an early requirement for extrinsic signals to intrinsic mechanisms. Thus, the cells in the nervous system acquire distinct fates in response to extrinsic signals, which activate repertoires of transcription factors in a region and cell type specific manner. LÄS MER

7. 20. Alloreactivity in stem cell transplantation

   Författare :Anna Nordlander; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Acute graft-versus-host disease (GVHD), relapse and graft rejection are the main complications after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this thesis was to achieve a better understanding of the alloreactivity seen after HSCT, focusing on graft rejection, but also including the graft-versus-leukemia (GVL) effect and GVHD. LÄS MER