Sökning: "stem cell regulation"

Visar resultat 1 - 5 av 267 avhandlingar innehållade orden stem cell regulation.

  1. 1. Novel Insights into Haematopoietic Stem Cell Regulation and Function

    Författare :Sarah Warsi; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematopoiesis; Haematopoietic stem cell; Stem cell regulation; Haematopoietic stem cell transplantation;

    Sammanfattning : The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which is used to treat many haematopoietic disorders. LÄS MER

  3. 2. Regulation of Mast Cell Survival

    Författare :Christine Möller; Gunnar Nilsson; Alf Grandien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; A1; Bfl-1; Bim; Bcl-2 family members; basophil; SCF; forkhead; survival; Patologi; Pathology; Patologi;

    Sammanfattning : Mast cells are long-lived effector cells of importance for both acute and chronic inflammations. Mast cells can be activated in many different ways, leading to the release of inflammatory mediators. In contrast to most other inflammatory cells, activated mast cells have the capacity to recover, regranulate and thereby be activated again. LÄS MER

  4. 3. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

    Författare :Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

    Sammanfattning : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. LÄS MER

  5. 4. Molecular regulation of hematopoietic stem cells

    Författare :David Bryder; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; Haematology; bone marrow transplantation; cytokines; Hematopoiesis; stem cells;

    Sammanfattning : Hematopoietic stem cells (HSCs) are ultimately responsible for the all mature blood cell production. They can primarily be found in the bone marrow (BM) at a low frequency (~0.02%). LÄS MER

  7. 5. Identification of stem cell factors - Novel protein-protein interactions and their functions

    Författare :Helena Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Tpt1; Npm1; Ncl; Oct4; Sox2; Nanog; SAF-A; cell proliferation; transcriptional regulation;

    Sammanfattning : Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon different molecular aspects regarding ES cells, primarily by finding novel stem cell protein-protein interactions and their functions. LÄS MER