Sökning: "spontaneously hypertensive rats"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden spontaneously hypertensive rats.

1. 1. Deviant sexual behavior, hormones and sex-chromosomal relationship : A study in the spontaneously hypertensive rat (SHR)

   Författare :Anders Wall; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; SHR; WKY; Rat; Copulatory performance; Deviant sexual behavior; Neuroendocrine mechanisms; Neonatal; Farmakologi; Pharmacological research; Farmakologisk forskning; Neurology; neurologi;

   Sammanfattning : The general aim of the present thesis was to gain insight into some biological factors that influencedeviant sexual performance. Two inbred strains selectively bred (hypertension) from the same Wistarrat colony were used: the spontaneously hypertensive rat (SHR) and its normotensive progenitor theWistar Kyoto rat (WKY). LÄS MER

3. 2. Effects of oestrogen on haemodynamic and vascular reactivity - A study in animal models and humans

   Författare :Lisa Brandin; Göteborgs universitet; []
   Nyckelord :adrenergic reactivity; endothelium; haemodynamic; hypertension; oestrogen; postmenopausal women; resistance arteries; spontaneously hypertensive rats; stress;

   Sammanfattning : Effects of Oestrogen on Haemodynamic and Vascular Reactivity A study in animal models and humans Lisa Brandin Institute of Medicine, Department of Emergency and Cardiovascular Medicine, Sahlgrenska University Hospital/Östra, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden ABSTRACT Previous studies have shown that oestrogen, the female sex hormone, plays a protective role in the cardiovascular system. However the site of action remains incompletely understood. LÄS MER

4. 3. Endothelium-derived substances and regional hemodynamics in experimental hypertension

   Författare :Sven-Olof Granstam; Uppsala universitet; []
   Nyckelord :Medical sciences; nitric oxide; endothelin; hypertension; rats; SHR; hemodynamics; blood pressure; blood flow; acetylcholine; carvedilol; microsphere method; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : The spontaneously hypertensive rat (SHR), a model for experimental hypertension, is considered to have similarities with essential hypertension in humans. Differences between SHR and normotensive Wistar Kyoto rats (WKY) in the vascular response to endothelial-derived substances such as nitric oxide (NO) have been intensively studied in vitro. LÄS MER

5. 4. Genetic differences in neuropathy and opioid responses in rats

   Författare :Aleksandra Bulka; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Allodynia; genetic difference; neuropathic pain; NMDA-receptor; opioids; rat strains; pharmacokinetics; tolerance.;

   Sammanfattning : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. LÄS MER

7. 5. Serotonergic and steroidal influences on impulsive behaviour in rats

   Författare :John L. Evenden; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; impulsivity; serotonin; 8-OH-DPAT; DOI; steroid; testosterone; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

   Sammanfattning : Impulsiveness is a trait contributing to the personality of all human beings to a greater and lesser extent. In a pathological form it can lead to impulsive behaviour which is an important component of many psychiatric and neurological disorders. LÄS MER