Sökning: "splice sites"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden splice sites.

1. 1. Splice site selection in Saccharomyces cerevisiae pre-mRNA splicing

   Författare :B G Mattias Luukkonen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pre-mRNA splicing is the process by which intervening sequences (introns) are removed from the coding sequences (exons) resulting in a mature messenger-RNA (mRNA). Splicing takes place in a large ribonucleoprotein complex termed the spliceosome, composed of several protein components and the five small nuclear RNAs (snRNAs) U I, U2, U4, U5 and U6. LÄS MER

3. 2. Design and application of RNA therapeutics for splice site mutations

   Författare :Burcu Bestas; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. LÄS MER

4. 3. Understanding the Noise : Spliceosomal snRNA Profiling

   Författare :Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. LÄS MER

5. 4. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing

   Författare :Heidi Törmänen Persson; Göran Akusjärvi; Stefan Schwartz; Marie Öhman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-33K; adenovirus; splicing; phosphorylation; localization; replication centers; L4-22K; MLTU; DNA-PK; DNA-dependent protein kinase; PKA; cAMP-dependent protein kinase; transcription sites; SR protein; Medical Virology; Medicinsk virologi;

   Sammanfattning : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. LÄS MER

7. 5. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

   Författare :Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

   Sammanfattning : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. LÄS MER