Sökning: "spindle cell tumors"
Visar resultat 6 - 10 av 13 avhandlingar innehållade orden spindle cell tumors.
6. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis
Sammanfattning : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. LÄS MER
7. Centrosome aberrations and tumor development
Sammanfattning : The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and transactivators of genes of importance for cell cycle progression. In the present thesis, the focus is on an important function that controls the segregation of the chromosomes during cell division to the next generation of two daughter cells. LÄS MER
8. Kaposi's sarcoma and malignant lymphomas in Tanzania during the AIDS epidemic
Sammanfattning : Kaposi s sarcoma (KS) studies Kaposi´s sarcoma (KS) is the most frequent AIDS tumor (AKS) and associated with HHV-8, but controversial whether a clonal tumor or mostly a reactive proliferation of endothelial spindle cells (SC). In the present studies AKS and endemic KS (EKS) biopsies were compared for expression of HHV-8-LANA, the lymphatic endothelial (LEC) markers LYVE-1 and Ki-67 (proliferation). LÄS MER
9. Morphologic and genetic features of sarcomas : improving diagnosis and exploring biomarkers
Sammanfattning : Sarcomas are malignant tumors of soft tissue and bone origin. They are a family of rare but diverse neoplasms which pose clinical challenges due to their heterogeneous properties. LÄS MER
10. AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
Sammanfattning : Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera which is found in four different clinico-epidemiological forms as Classic KS (CKS), Iatrogenic KS (IKS), Endemic KS (EKS) and AIDS-associated KS (AKS). All KS forms develop from early stages of patch/plaque to late, nodular tumors and are associated with Kaposi's sarcomaassociated herpesvirus or human herpesvirus-8 (KSHV/ HHV-8). LÄS MER