Sökning: "spike gene"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden spike gene.

  1. 1. Normalization and analysis of high-dimensional genomics data

    Författare :Mattias Landfors; Patrik Rydén; Rebecka Jörnsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; normalization; pre-processing; microarray; downstream analysis; evaluation; sensitivity; bias; genomics data; gene expression; spike-in data; ChIP-chip; Mathematical Statistics; matematisk statistik;

    Sammanfattning : In the middle of the 1990’s the microarray technology was introduced. The technology allowed for genome wide analysis of gene expression in one experiment. Since its introduction similar high through-put methods have been developed in other fields of molecular biology. LÄS MER

  3. 2. Immunoglobulin gene usage and affinity maturation in antiviral antibodies

    Författare :Pradeepa Pushparaj; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of antiviral antibodies induced by infection and vaccination. LÄS MER

  4. 3. Normalization and Differential Gene Expression Analysis of Microarray Data

    Författare :Magnus Åstrand; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : DNA microarray technologies have the capability of simultaneously measuring the abundance of thousands of mRNA-sequences. Analysis of microarray data involves many different steps such as image analysis, background correction, and normalization, but also more classical statistical analysis such as testing for significant differences between groups of arrays. LÄS MER

  5. 4. From single-cell transcriptomics to single-molecule counting

    Författare :Saiful Islam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : RNA-sequencing (RNA-seq) technology has been progressing so fast in the last few years and made it possible to perform transcriptome analysis at single-cell level that was even unimaginable a few years before. Nowadays, the importance of gene expression analysis at the single-cell level is increasingly appreciated for the study of complex heterogeneous tissue. LÄS MER

  7. 5. Molecular characterization and detection of infectious bronchitis virus

    Författare :hussain Shahid Abro; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : This thesis deals with the molecular characterization and detection of infectious bronchitis virus (IBV), an important pathogen that causes heavy losses in the poultry populations worldwide. The aim of the research was to better understand the molecular characteristics of the virus and to investigate the factors behind the continuous emergence of new genetic variants and the occurrence of outbreaks. LÄS MER