Sökning: "sphingosine-1-phosphate"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet sphingosine-1-phosphate.

  1. 6. The ApoM/S1P-complex: its role in vascular inflammatory disease and interaction with S1P-receptors

    Författare :Cecilia Frej; Malmö Klinisk kemi; []
    Nyckelord :lipoproteins; Apolipoproteins; Phospholipids; sepsis; Atherosclerosis;

    Sammanfattning : HDL is believed to be protective against cardiovascular disease (CVD) via the reverse cholesterol transport and anti-inflammatory actions in the vessel. Apolipoprotein M (apoM) is an apolipoprotein mainly associated with HDL. Recently ApoM was proven tobe the main carrier of Sphingosine 1-phosphate (S1P) in circulation. LÄS MER

  3. 7. On the stimulatory effect of microglial cells on angiogenesis

    Författare :Simin Rymo; Göteborgs universitet; []
    Nyckelord :microglia; angiogenesis; aortic ring;

    Sammanfattning : ABSTRACT Angiogenesis, the process by which new vessels sprout from pre-existing vessels, is fundamental to development, tissue growth and repair. The main aim of this thesis was to investigate the role of microglia on angiogenesis. We adapted the rat ex vivo/in vitro aortic ring model to the mouse in a 3-D culture system. LÄS MER

  4. 8. Apolipoprotein M – Studies of Structure and Function

    Författare :Josefin Ahnström; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; signal peptidase; signal peptide; crystallization; Apolipoprotein; lipocalin; HDL; coronary heart disease;

    Sammanfattning : Apolipoprotein M (apoM), a 25 kDa plasma protein, is found in all major lipoprotein classes, although the majority is found in high density lipoproteins (HDL). ApoM has been suggested to be involved in the formation of and adding to the antiatherogenic functions of HDL, but its function is still not completely known. LÄS MER

  5. 9. On the role of bioactive sphingolipids and their metabolizing enzymes in cancer

    Författare :Dilruba Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas sphingosine 1-phosphate (S1P) mediates cell proliferation, invasion, angiogenesis and metastasis. LÄS MER

  7. 10. Studies of the tumor-vasculature interface : role of TGF-beta 1-induced epithelial to mesenchymal transition

    Författare :Mei-Fong Pang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tumor metastasis is a complex multistep process. Among key steps that occur during metastatic spread are acquisition of tumor cell motility, intravasation of tumor cells into blood or lymphatic vessels and extravasation of tumor cells at distal sites. However, the precise mechanisms that govern these metastatic steps remain elusive. LÄS MER