Sökning: "sphingosine-1-phosphate"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet sphingosine-1-phosphate.

  1. 1. The significance of blood vessels in organogenesis and cadherins in exploratory behaviour

    Författare :Josefina Edsbagge; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :; pancreas; sphingosine-1-phosphate; endothelium; epithelial-to-mesenchymal interactions; Cre loxP-system; cadherins; rearing;

    Sammanfattning : Organogenesis of epithelial organs requires interaction between epithelial andmesenchymal tissues. In pancreas development three different mesenchymal derivedstructures, the notochord, the endothelial cells and the splanchnic mesenchyme inducespecification, growth and further differentiation of the pancreatic epithelium. LÄS MER

  2. 2. Palmitate-induced Apoptosis in Insulin-producing β-cells

    Författare :Kristofer Thörn; Peter Bergsten; Claes Wollheim; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ER stress; apoptosis; palmitate; sphingosine-1-phosphate; ceramide; beta-cell; fatty acid; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. LÄS MER

  3. 3. The role of N-cadherin and S1P/S1P1 in pancreas development

    Författare :Jenny Johansson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Organogenesis of epithelial organs requires interaction between epithelial and mesenchymal tissues. During pancreas development, mesenchyme-derived structures induce specification, growth and differentiation of pancreatic epithelial cells. LÄS MER

  4. 4. Mechanisms of platelet-mediated fibroblast proliferation

    Författare :Cecilia Berg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Wound healing is a multicomponent event that involves a network of molecular and cellular crosstalk between cells, including leukocytes, platelets and fibroblasts. Despite increased knowledge over the past decades regarding the regulation of cell and tissue growth, the inter- and intracellular systems that control wound healing are incompletely understood. LÄS MER

  5. 5. The ApoM/S1P-complex: its role in vascular inflammatory disease and interaction with S1P-receptors

    Författare :Cecilia Frej; Malmö Klinisk kemi; []
    Nyckelord :lipoproteins; Apolipoproteins; Phospholipids; sepsis; Atherosclerosis;

    Sammanfattning : HDL is believed to be protective against cardiovascular disease (CVD) via the reverse cholesterol transport and anti-inflammatory actions in the vessel. Apolipoprotein M (apoM) is an apolipoprotein mainly associated with HDL. Recently ApoM was proven tobe the main carrier of Sphingosine 1-phosphate (S1P) in circulation. LÄS MER