Sökning: "spheroid"
Visar resultat 21 - 25 av 39 avhandlingar innehållade ordet spheroid.
21. Deep Neural Networks and Image Analysis for Quantitative Microscopy
Sammanfattning : Understanding biology paves the way for discovering drugs targeting deadly diseases like cancer, and microscopy imaging is one of the most informative ways to study biology. However, analysis of large numbers of samples is often required to draw statistically verifiable conclusions. LÄS MER
22. Accurate quadrature and fast summation in boundary integral methods for Stokes flow
Sammanfattning : This thesis concerns accurate and efficient numerical methods for the simulation of fluid flow on the microscale, known as Stokes flow or creeping flow. Such flows are important, for example, in understanding the swimming of microorganisms, spreading of dust particles, as well as in developing new nano-materials, and microfluidic devices that can be used for on-the-fly analysis of blood samples, among other things. LÄS MER
23. Construction, expression and evaluation of anti-keratin 8 single-chain antibody fragments
Sammanfattning : Antibodies are glycoproteins specifically binding to a variety of antigens and today extensively used in prevention, diagnosis and treatment of diseases. Carcinomas originate from epithelial tissues and are the most common forms of human malignancies. In the necrotic areas of carcinomas significant amounts of keratins (K) are found extracellularly. LÄS MER
24. Formation of Composite Islet Grafts : A novel strategy to promote islet survival and revascularization
Sammanfattning : The islets of Langerhans are small and delicate spheroid organs scattered in the pancreas responsible for insulin production. Transplantation of isolated islets is a beneficial therapy for patients with a severe form of type 1 diabetes. LÄS MER
25. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Sammanfattning : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. LÄS MER