Sökning: "spectinomycin"

Hittade 4 avhandlingar innehållade ordet spectinomycin.

  1. 1. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids

    Författare :Sandesh Kanchugal P; Maria Selmer; Ditlev Brodersen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; streptomycin; spectinomycin; X-ray crystallography; methyltransferase; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. LÄS MER

  3. 2. Characterization of a site-specific gene-transfer mechanism in bacteria

    Författare :Karin Hansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Sammanfattning : Integrons capture and rearrange single genes borne on mobile units called cassettes using site-specific recombination. The integrons increase the variation of antibiotic resistance among bacterial plasmids and may also reorganize clustered genes in bacterial genomes. LÄS MER

  4. 3. Antibiotic interactions and selection for resistance in biofilms

    Författare :Po-Cheng Tang; Dan I. Andersson; Karin Hjort; Mark Webber; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; Mikrobiologi; Microbiology;

    Sammanfattning : The challenges posed by antibiotic-resistant bacteria in treating infections, particularly those associated with biofilms, require a deeper understanding of this lifestyle and its connection to resistance selection. Additionally, gaining insights into drug interactions is crucial for enhancing combination treatment efficacy and mitigating resistance development. LÄS MER

  5. 4. Recent trends in the epidemiology of gonorrhoea in Sweden : the role of importation and core groups

    Författare :Torsten Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria gonorrhoeae; epidemiology; core groups; importation; serovar; PFGE; antimicrobial resistance; men who have sex with men MSM ;

    Sammanfattning : In 1997 the gonorrhoea incidence in Sweden started to rise from a low-prevalent level after some 25 years of steady decline. The rise has continued and coincides with similar trends in other sexual transmitted infections (STIs) and in other Western industrialized countries. LÄS MER