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  1. 1. Haematopoietic Serine Proteases : A Cleavage Specificity Analysis

    Författare :Michael Thorpe; Lars Hellman; Urban Gullberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

    Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER

  3. 2. PARN – The Tail End : Function and mechanisms of specificity and processivity

    Författare :Mikael Nissbeck; Anders Virtanen; Renée Schroeder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Poly A specific ribonuclease; Adenosine; Specificity; Processivty; Telomere biology disorders; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Poly(A)-specific ribonuclease (PARN) is an exoribonuclease that is processive, poly(A) specific and cap-binding. PARN deadenylates the poly(A) tails present on a subset of mRNAs and non-coding RNAs, including among others certain snoRNAs, miRNAs and precursor rRNAs. LÄS MER

  4. 3. Characterization of antibody specificity using peptide array technologies

    Författare :Björn Forsström; Mathias Uhlén; Markus Templin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody; Epitope mapping; Peptide array; Suspension bead array; Antigen; Specificity; Cross-reactivity; Immunization; Immunogenicity; Bioteknologi; Biotechnology;

    Sammanfattning : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. LÄS MER

  5. 4. Substrate specificity of protein kinases studied with synthetic peptides

    Författare :Reet Toomik; Uppsala universitet; []
    Nyckelord :Medical sciences; protein kinase A; protein kinase C; substrate; peptide; specificity; stereospecificity; assay; SPOTS peptides; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : This thesis concentrates on the substrate specificities of protein kinases A and C (PKA, PKC). Synthetic peptides are used for that purpose, both in soluble and cellulose membrane-bound form. The, stereospecificity of both protein kinases was studied with D-amino acid containing synthetic peptides. LÄS MER

  7. 5. Cleavage Specificity of Mast Cell Chymases

    Författare :Mattias K. Andersson; Lars Hellman; Gunnar Pejler; Per Venge; Uppsala universitet; []
    Nyckelord :Biology; Immunology; Mast cell; Serine protease; Chymase; Cleavage specificity; Phage display; Biologi;

    Sammanfattning : Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in IgE mediated allergies. However, they also provide beneficial functions to the host, e.g. in bacterial and parasitic defence. LÄS MER