Sökning: "spatial transcriptomics ST"

Hittade 5 avhandlingar innehållade orden spatial transcriptomics ST.

  1. 1. Spatial Tissue Mapping on Joint Biopsies from Arthritis Patients

    Författare :Konstantin Carlberg; Patrik Ståhl; Vivianne Malmström; Anna-Karin Hultgård Ekwall; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Immune prediction; Rheumatoid arthritis; Spatial RIN; Spatial Transcriptomics; Spondyloarthritis; Biotechnology; Bioteknologi;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects joints, causing discomfort and pain that severely reduces the life quality of affected individuals. Its etiology is largely unknown, but some pathophysiological mechanisms have been identified. LÄS MER

  2. 2. Spatially Resolved Gene Expression Analysis

    Författare :Michaela Asp; Joakim Lundeberg; Patrik Ståhl; Thierry Voet; KTH; []
    Nyckelord :RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; Biotechnology; Bioteknologi;

    Sammanfattning : Spatially resolved transcriptomics has greatly expanded our knowledge of complex multicellular biological systems. To date, several technologies have been developed that combine gene expression data with information about its spatial tissue context. LÄS MER

  3. 3. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Författare :Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Nyckelord :RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Biotechnology; Bioteknologi;

    Sammanfattning : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. LÄS MER

  4. 4. Using systems genetics to explore the complexity of leaf shape variation in Populus tremula

    Författare :Barbara Terebieniec; Nathaniel Street; Chung-Jui Tsai; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Populus; Arabidopsis; systems biology; systems genetics; spatial transcriptomics ST ; single nucleotide polymorphism SNP ; Genome wide associations study GWAS ; expression GWAS eGWAS ; molekylärbiologi; Molecular Biology;

    Sammanfattning : Leaves are essential for sustaining humanity as they function as the energy and oxygen-producing organ of plants. Intensive research on physiological processes has contributed immensely to our understanding of the function of leaves. However, comparatively little is known about how leaf size and shape is determined. LÄS MER

  5. 5. Molecular and Spatial Profiling of Prostate Tumors

    Författare :Emelie Berglund; Joakim Lundeberg; Päivi Östling; KTH; []
    Nyckelord :Biotechnology; Bioteknologi;

    Sammanfattning : Every cancer tumor is unique, with characteristics that change over time. The evolution of a full-blown malignancy from a single cell that gives rise to a heterogeneous population of cancer cells is a complex process. LÄS MER