Sökning: "spatial analyses"

Visar resultat 1 - 5 av 391 avhandlingar innehållade orden spatial analyses.

1. 1. Spatial transcriptome and epigenome analysis with focus on prostate cancer

   Författare :Maja Marklund; Joakim Lundeberg; Patrik Ståhl; Marc Friedländer; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spatial; Spatial Transcriptomics; Spatial ATAC; epigenomics; Biotechnology; Bioteknologi;

   Sammanfattning : Each cancer is unique, and therefore the use of general treatments are often suboptimal. If we can understand the mechanisms of cancer development, we might be able to develop effective treatments tailored to each patient. Our bodies are complex three-dimensional structures and how things are organized correlate with proper functioning. LÄS MER

3. 2. Spatial immune analyses in clinical cancer tissue

   Författare :Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. LÄS MER

4. 3. Landscape Dynamics : Spatial analyses of villages and farms on Gotland AD 200-1700

   Författare :Gustaf Svedjemo; Frands Herschend; Helene Martinsson-Wallin; Jan Henrik Fallgren; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Gotland; Archaeology; History; Historical maps; Roman Iron Age; Migration Period; Middle Ages; Village; Village formation; Farm; Settlement archaeology; Spatial analyses; GIS; Prediction modelling.; Gotland; Arkeologi; Historia; Historiska kartor; Romersk järnålder; Folkvandringstid; By; Bybildning; Gård; Bebyggelsearkeologi; rumsliga analyser; GIS; Geografiska informationssystem; prediktionsmodellering;

   Sammanfattning : This dissertation deals with the long-term dynamics and fluctuations of settlements on Gotland for the period from AD 200 up until early modern times. The settlement structure on Gotland is most often described as very stable and consisting of solitary farms, established in the Iron Age. LÄS MER

5. 4. Computational methods for analysis of spatial transcriptomics data : An exploration of the spatial gene expression landscape

   Författare :Alma Andersson; Joakim Lundeberg; Omer Bayraktar; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; spatial transcriptomics; machine learning; data analysis; RNA-seq; probabilistic; statistical; models; Biotechnology; Bioteknologi;

   Sammanfattning : Transcriptomics techniques, whether in the form of bulk, single cell/nuclei, or spatial methods have fueled a substantial expansion of our knowledge about the biological systems within and around us. In addition, the rate of innovation has accelerated over the last decade, resulting in a multitude of technological advances and new methods for generation of transcriptomics data. LÄS MER

7. 5. The immune microenvironment in mantle cell lymphoma : Targeted liquid and spatial proteomic analyses

   Författare :Lavanya Lokhande; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; proteomic analyses; spatial analysis; Biomarker discovery; immune microenviroment; serum proteomics;

   Sammanfattning : The complex interplay of the tumour and immune cells affects tumour growth, progression, and response to treatment. Restorationof effective immune response forms the basis of onco-immunology, which further enabled the development of immunotherapy. LÄS MER