Sökning: "somatostatin receptor 2 expression"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden somatostatin receptor 2 expression.

1. 6. Somatostatin effects on the proteome of human prostate cancer cells

   Författare :Zhaoxu Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer. The aim of this thesis was to study somatostatin effects on the proteome of prostate cancer cells, to identify differences in protein expression in androgen dependent and androgen independent prostate cancer cells, and to explore possibilities to enhance the somatostatin receptor expression through pre-treatment with sms, 5-aza and TSA (DNA methylation/HDAC inhibitors). LÄS MER

3. 7. Somatostatin, dendritic cells and peptide T in psoriasis : a clinical, immunohistochemical and functional study

   Författare :Toomas Talme; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Peptide T is an octapeptide designed to block the CD4 receptor. In a phase 1 study 9 psoriasis patients were treated with 2 mg peptide T i.v. once daily for 28 days and followed for a further 3 months. LÄS MER

4. 8. Novel Circulating and Tissue Biomarkers for Small Intestine Neuroendocrine Tumors and Lung Carcinoids

   Författare :Tao Cui; Valeria Giandomenico; Kjell Öberg; Apostolos V. Tsolakis; Marco Volante; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumors; lung carcinoids; Ma2 autoantibodies; immunohistochemistry; olfactory receptor 51E1; blood samples; antibody suspension bead array; 小肠神经内分泌肿瘤，肺类癌，Ma2自身抗体，免疫组化，嗅觉受体蛋白51E1， 血液样本，抗体悬浮磁珠阵列; Endokrinologi och Diabetologi; Endocrinology and Diabetology; Lung Medicine; Lungmedicin; Molecular Biology; Molekylärbiologi; Oncology; Onkologi;

   Sammanfattning : Small intestine neuroendocrine tumors (SI-NETs) and lung carcinoids (LCs) are relatively indolent tumors, which originate from neuroendocrine (NE) cells of the diffuse NE system. Metastases can spread before diagnosis. Thus, potential cures become unavailable, which entitles new biomarker development. LÄS MER

5. 9. Leptin targets in the brain regulating body weight : receptors and down-stream mediators of leptin in neurons of the hypothalamus and brainstem

   Författare :Marie-Louise Håkansson Ovesjö; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :AGRP; antibody; arcuate nucleus; blood-brain-barrier; body weight; brainstem; CART; CRH; DMX; food intake; GABA; GAD; galanin; hypothalamus; immunohistochemistry; in situ hybridization; lateral hypothalamic area; leptin; leptin receptor; MCH; NPY; obesity; Ob-R; Ob-Rb; oxytocin; paraventricular nucleus; POMC; somatostatin; serotonin; STAT3; supraoptic nucleus; transcription factor; vasopressin; VGAT;

   Sammanfattning : Obesity is a disease which has become a global epidemic that is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health in the world. In particular, obesity is associated with diabetes mellitus, hypertension and coronary heart disease. LÄS MER

7. 10. Gastric acid secretion and gut peptides : mechanisms involved in inflammatory response

   Författare :Tobias Rudholm Feldreich; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The regulation of gastric acid secretion is complex and involves endocrine, paracrine, and neurocrine mechanisms. Among these, the interconnecting cross-talk between different gut peptides is an important part in the control of acid secretion. LÄS MER