Sökning: "somatic"
Visar resultat 1 - 5 av 551 avhandlingar innehållade ordet somatic.
1. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes
Sammanfattning : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. LÄS MER
2. Prognostic and Predictive Somatic Mutations in Colorectal Cancer
Sammanfattning : Colorectal cancer (CRC) is the third most incident and the second deadliest cancer worldwide. Even though CRC incidence is strongly correlated with age, it has been increasing in developing countries and younger individuals. LÄS MER
3. Somatic Genetic Variation in Children: from Mosaicism to Cancer
Sammanfattning : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. LÄS MER
4. Nqabayo’s Nomansland: San Rock Art and the Somatic Past
Sammanfattning : The most significant challenge facing modern southern African rock art research is the integration of rock paintings into the construction of San history. This challenge is made all the more difficult because of poor chronological control over the images. LÄS MER
5. Psychological processes in somatic disease
Sammanfattning : The course of disease was investigated in three studies of patients with rheumatoid arthritis (RA). The aim was to explore changes in clinical course during and after psychodynamically oriented psychotherapy, with one session of 60-90 minutes per week for 3.3 years as a median. LÄS MER