Sökning: "somatic hypermutation"

Visar resultat 11 - 15 av 22 avhandlingar innehållade orden somatic hypermutation.

  1. 11. The CD40 Receptor - Target,Tool and Technology

    Författare :Peter Ellmark; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

    Sammanfattning : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. LÄS MER

  3. 12. Reappraising prognosis in chronic lymphocytic leukemia

    Författare :Panagiotis Baliakas; Richard Brandell Rosenquist; Clemens Wendtner; Uppsala universitet; []
    Nyckelord :CLL; prognosis; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) exhibits remarkable clinical heterogeneity likely reflecting the underlying biological heterogeneity. The genetic landscape of CLL has been recently enriched with mutations within a number of genes proposed as novel prognostic markers. LÄS MER

  4. 13. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes

    Författare :Linda Zander; Göteborgs universitet; []
    Nyckelord :B lymphocyte; germinal centre; transformation; serum-free; MHC class II; bare lymphocyte syndrome; extracellular proteins; DNA repair; Polymerase ?;

    Sammanfattning : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. LÄS MER

  5. 14. Dissection of HIV-1 Env-specific B cell responses in nonhuman primates

    Författare :Christopher Sundling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vaccine-induced protection is generally mediated by long-lived antigen-specific B cell responses. Most licensed vaccines target pathogens that display relatively low variability, but for highly variable pathogens, such as HIV-1, vaccine development is more challenging. LÄS MER

  7. 15. Impairment of B cell trafficking and differentiation during HIV-1 infection

    Författare :Vu Phuong Linh Dang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number of memory B cells, increased levels of activation markers on B cell surface and plasmacytosis. LÄS MER