Sökning: "solubility"
Visar resultat 11 - 15 av 476 avhandlingar innehållade ordet solubility.
11. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption
Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER
12. Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica
Sammanfattning : Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. LÄS MER
13. Amyloid β peptide: from monomer solubility to fibril structure
Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER
14. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility
Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER
15. Model for activity coefficients and solubilities of Na2CO3 and Na2SO4 in high-temperature solutions
Sammanfattning : Scaling of sodium sulfate and sodium carbonate double salts has long been recognized as a problem in the black liquor evaporation process. These salts are abundant in black liquor and often tend to precipitate on heat transfer areas, thereby significantly decreasing the heat transfer efficiency. LÄS MER