Sökning: "solid phase organic chemistry"
Visar resultat 1 - 5 av 99 avhandlingar innehållade orden solid phase organic chemistry.
1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy
Sammanfattning : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. LÄS MER
2. Investigating polymorphism in small molecules using three-dimensional electron diffraction
Sammanfattning : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. LÄS MER
3. Glycoconjugates : Solid-phase synthesis and biological applications
Sammanfattning : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. LÄS MER
4. Immobilisation of Ru-Based Molecular Catalysts for Electrochemical Water Oxidation
Sammanfattning : Artificial photosynthesis requires catalysts for efficient and selective conversions of small molecules. Molecular catalysts are advantageous to use in these instances as they offer precise control over chemical reactivity. LÄS MER
5. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides
Sammanfattning : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. LÄS MER