Sökning: "small-bowel biopsy"

Hittade 5 avhandlingar innehållade orden small-bowel biopsy.

  1. 1. Screening Detected Celiac Disease in Children

    Författare :Charlotta Webb; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac disease; screening; prevalence; small-bowel biopsy; enteropathy; transglutaminase; gluten-free diet; adherence;

    Sammanfattning : Background: The prevalence of celiac disease (CD) is estimated to be around 1%, but most CD cases are undiagnosed. Sweden experienced an epidemic of clinically detected celiac disease in children younger than 2 years of age, partly due to changes in infant feeding practices, were the amount of gluten and age at introduction was changed. LÄS MER

  3. 2. Pathogenetic mechanisms in irritable bowel syndrome

    Författare :Hans Törnblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Irritable bowel syndrome; functional gastrointestinal disorder; immunohistochemistry; full-thickness biopsy; enteric nervous system; autoantibody; gastroenteritis; risk factor;

    Sammanfattning : Aims of the thesis: To study new pathogenetic mechanisms in IBS; to find out if IBS is a neuromuscular disease affecting the small bowel; to study humoral factors in gut dysmotility associated with visceral neuropathy; and to study the natural history of post-infectious gastro-intestinal (GI) symptoms and risk factors for their development. Material and methods: In studies I and II, full-thickness jejunum biopsies from patients with severe IBS were investigated with immunohistochemistry. LÄS MER

  4. 3. Childhood coeliac disease : clinical aspects of heredity, diagnosis and dietary therapy

    Författare :Lotta Högberg; Anders Dannaeus; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Childhood coeliac disease (CD) is defined as a lifelong disorder, in which the small bowel mucosa is abnormal as a result of exposure to gluten in the diet. The mucosal damage improves on treatment with a gluten-free diet, but recurs within two years of reintroduction of gluten. LÄS MER

  5. 4. The Significance of IgG Antibodies against Tissue Transglutaminase in Coeliac Disease

    Författare :Ingrid Dahlbom; Birgitta Heyman; Tony Hansson; Knut Lundin; Uppsala universitet; []
    Nyckelord :Immunology; Coeliac disease; Tissue transglutaminase; Endomysium; IgG antibodies; Immunologi;

    Sammanfattning : Coeliac disease (CD) is a multifactorial disease of the small intestine. In genetically predisposed individuals the, ingestion of cereals leads to a remodulation of the mucosal architecture, and the production of autoantibodies against tissue transglutaminase (tTG). The treatment is a lifelong gluten-free diet. LÄS MER

  7. 5. Tissue transglutaminase autoantibodies in childhood celiac disease

    Författare :Daniel Agardh; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; transplantation; villous atrophy; T cells; serological marker; screening; intestinal mucosa; children; celiac disease; CD25; CD8; CD4; autoantibodies; B cells; gluten-free diet; autoimmunity;

    Sammanfattning : Celiac disease is a prevalent small bowel disease in children caused by permanent intolerance against gliadin, which is the alcohol-soluble fraction of the cereal protein gluten in wheat, rye and barley. Celiac disease is characterized by an inflammatory infiltrate of CD4+ T lymphocytes in the intestinal mucosa leading to damage of villous structure and loss of absorptive surface. LÄS MER