Sökning: "small molecule drugs"

Visar resultat 1 - 5 av 95 avhandlingar innehållade orden small molecule drugs.

  1. 1. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

    Författare :Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

    Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER

  3. 2. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER

  4. 3. Small-Molecule Galectin Inhibitors - On Tweezers and Talosides

    Författare :Christopher Öberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. LÄS MER

  5. 4. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs

    Författare :Tove Selvin; Mårten Fryknäs; Rolf Larsson; Claes Andersson; Malin Jarvius; Brinton Seashore-Ludlow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; anti-cancer drugs; preclinical modeling; drug screening; repurposing;

    Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER

  7. 5. Capillary electrophoresis mass spectrometry applied to structural proteomics and small molecule analysis

    Författare :Jordan Aerts; Erik T. Jansson; Per E. Andrén; Petr Man; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Capillary Electrophoresis Mass Spectrometry; Hydrogen Deuterium Exchange Mass Spectrometry; Enantioselective Separations; Drugs of Abuse; Analytical Chemistry; Analytisk kemi; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Capillary electrophoresis with mass spectrometric (CE–MS) detection offers a separation method without equal in terms of flexibility, utility, and cost efficiency. Here we demonstrate precisely this through the application of several laboratory-built CE–MS instruments for the separation of brain metabolites in non-primates, enantioselective separations of synthetic anesthetic metabolites in fractionated pony urine, application in structural proteomics workflows, and identification of exogenous alkaloid biotransformationproducts in human cerebrospinal fluid (CSF). LÄS MER