Sökning: "skeletal disorders"
Visar resultat 21 - 25 av 76 avhandlingar innehållade orden skeletal disorders.
21. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming
Sammanfattning : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. LÄS MER
22. Novel pathways regulating glucose and lipid metabolism in human skeletal muscle
Sammanfattning : The utilization of glucose and lipids as energy substrates in skeletal muscle is strictly regulated. As skeletal muscle is the body s chief consumer of glucose and lipids, it plays a critical role in the maintenance of whole-body homeostasis. LÄS MER
23. Cytogenetic and molecular analysis of chromosomal rearrangements associated with neuropsychiatric disorders
Sammanfattning : Genetic factors are important in the aetiology of neuropsychiatric disorders. Analysis of chromosomal abnormalities associated with these disorders may provide locus specific information for the identification of candidate genes and, subsequently, for our understanding of brain development and functioning. LÄS MER
24. Detecting novel effects of exercise or AMPK activation in human skeletal muscle
Sammanfattning : Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine monophosphate-activated protein kinase (AMPK). LÄS MER
25. Diabetes, obesity and exercise in skeletal muscle : effects on gene expression and DNA methylation
Sammanfattning : Type 2 diabetes, obesity and depression are growing concerns for human health. Physical exercise is a known protective factor against these disorders, although the underlying mechanisms are incompletely understood. LÄS MER