Sökning: "skeletal disorders"

Visar resultat 11 - 15 av 76 avhandlingar innehållade orden skeletal disorders.

  1. 11. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Författare :Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. LÄS MER

  3. 12. Explaining occupational disorders and work ability among home care workers

    Författare :Lotta Dellve; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Occupational diseases; work injury; musculoskeletal; sick leave; retirement; work ability; home care; home care service; home health aides; nursing personnel;

    Sammanfattning : The overall aim of this thesis was to investigate what factors and conditions contribute to explain the incidences of reported occupational disorders (occupational injuries and work-related diseases and symptoms) and work ability (long-term work ability, long-term sick leave and disability pension) among home care workers (HCWs).Factors at three levels were investigated in this thesis: the macro-organisational level, the workplace level and the individual level. LÄS MER

  4. 13. The role of SUMO pathway in pathophsiology of skeletal muscle

    Författare :Arvind Venkat Namuduri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino acids. LÄS MER

  5. 14. Cellular studies of neuromuscular disorders related to the sarcomeric proteins

    Författare :Saba Abdul-Hussein; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myogenesis; myoblast; sarcomeric myopathy; TPM2; TRIM54; TRIM63;

    Sammanfattning : Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number of different cardiac and skeletal muscle diseases. LÄS MER

  7. 15. Genetic and pathophysiological study of desmin derangements in cardiac disorders

    Författare :Anna Kostareva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from mechanical stress during contractionrelaxation process. LÄS MER