Sökning: "size exclusion chromatography"

Visar resultat 11 - 15 av 61 avhandlingar innehållade orden size exclusion chromatography.

  1. 11. Characterisation of kraft pulps by size-exclusion chromatography and kraft lignin samples by capillary zone electrophoresis

    Författare :Elisabeth Sjöholm; KTH; []
    Nyckelord :;

    Sammanfattning : In the present thesis two analytical methods forcharacterisation of underivatised pulp and lignin samplesobtained from kraft pulping of hardwood and softwood areevaluated. The first method is the use of lithiumchloride/N,N-dimethylacetamide (LiCl/DMAc) for dissolution andsize-exclusion chromatography (SEC) of pulps. LÄS MER

  2. 12. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    Författare :Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER

  3. 13. New Mass Spectrometric Methods for Structure Analysis of Carboxymethyl Cellulose

    Författare :Jonas Enebro; Sigbritt Karlsson; Dane Momcilovic; Ulf Germgård; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carboxymethyl cellulose; substituent distribution; rheology; enzyme hydrolysis; cellulase; permethylation; liquid chromatography; MALDI; ESI; mass spectrometry; Polymer chemistry; Polymerkemi;

    Sammanfattning : Carboxymethyl cellulose (CMC) is a cellulose derivative, made from cellulose by introduction of carboxymethyl groups along the molecules. The properties of CMC are affected by several parameters where the molar mass and molar mass distribution, degree of substitution (DS) and the distribution pattern along, and between, the cellulose molecules are the most prominent. LÄS MER

  4. 14. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

    Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER

  5. 15. Environmentally Degradable Polyethylene : Effects of Additives and Environment on the Degradation and Degradation products

    Författare :Farideh Khabbaz; KTH; []
    Nyckelord :LDPE; polyethylene; oxidative degradation; photo-oxidation; thermo-oxidation; degradation products; photosensitisers; pro-oxidant; starch; master-batch; gas chromatography mass-spectrometry; GC-MS; solid phase microextraction; SPME;

    Sammanfattning : This thesis summarises and compares the influences ofdifferent additives (photosensitisers, pro-oxidants, abiodegradable filler) on blown low-density polyethylene (LDPE)films during photo- and thermal degradation with respect tochemical changes in the polymer matrices and identifieddegradation products. Additives studied were irondimethyldithiocarbamate (FeDMC), nickel dibutyldithocarbamate(NiDBC), carbon black, starch, a pro-oxidant that consisted ofmanganese stearate together with styrene butadiene rubber (SBR)or natural rubber (NR) and a master batch containing linearLDPE, starch and pro-oxidant. LÄS MER