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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Novel human in vitro systems for studies of drug inducted hepatotoxicity

   Författare :Louise Sivertsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. LÄS MER

3. 2. Characterisation of mammalian cell culture processes with NIR spectroscopy

   Författare :Per Sivertsson; KTH; []
   Nyckelord :near-infrared NIR spectroscopy; cell culture; mammalian cell culture; characterisation; glucose; lactate; ammonia; cell content; viability; multivariate analysis; principal component analysis PCA ; partial least squares regression PLS ; score plo;

   Sammanfattning : The importance of recombinant proteins produced by mammaliancell culture has increased dramatically due to the discoveriesin the field of recombinant biotechnology. Therefore,optimising and gaining process knowledge about cell culture hasalso gained in interest. LÄS MER

4. 3. Dark matter in and around stars

   Författare :Sofia Sivertsson; Tommy Ohlsson; Steen Hansen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dark matter; early universe; Astroparticle physics; Astropartikelfysik;

   Sammanfattning : There is by now compelling evidence that most of the matter in the universe is in the form of dark matter, a form of matter quite different from the matter we experience in every day life. The gravitational effects of this dark matter have been observed in many different ways but its true nature is still unknown. LÄS MER

5. 4. Oxygen Metabolism in Experimental Kidney Disease

   Författare :Ebba Sivertsson; Fredrik Palm; Peter Hansell; Jenny Nyström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; kidney oxygenation; mitochondria; proteinuria; uncoupling protein; adenosine nucleotide transporter; diabetes; hyperthyroidism; thyroid hormone; hypertension; angiotensin II; CDK; AST-120; rats; mice; Fysiologi; Physiology;

   Sammanfattning : Tubulointerstitial hypoxia has been proposed a unifying mechanism behind the development of chronic kidney disease (CKD), regardless of primary diagnosis. Important factors that contribute to the development of hypoxia are reduced bioavailability of nitric oxide (NO), oxidative stress and mitochondria uncoupling. LÄS MER

7. 5. Criminal Careers in the Long Run : Patterns and Predictions of Criminal Convictions across Age, Time, and Gender

   Författare :Fredrik Sivertsson; Anders Nilsson; Olof Bäckman; Torbjørn Skardhamar; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Criminal career; Recidivism; Life course; Longitudinal; Birth cohort; Gender; kriminologi; Criminology;

   Sammanfattning : Why is it that a small proportion of the population accounts for the majority of crime? This question has stimulated a great deal of theoretical and methodological controversy in criminology. In essence, the debate is rooted in different theoretical underpinnings of continuity and change in crime, and the extent to which it is possible to foresee a life of crime by zeroing in on at-risk juvenile offenders. LÄS MER