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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Mechanisms of endothelial cell dysfunction in Wegener's granulomatosis

    Författare :Carolina Holmén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Wegener´s granulomatosis; vasculitis; anti-endothelial cell antibody; circulating endothelial cell; vascular adhesion protein 1; MHC class-I related chain A;

    Sammanfattning : Vasculitides are a heterogeneous group of disorders that share a common feature of blood vessel inflammation. A major cell type of the blood vessel affected is the endothelial cell (EC). LÄS MER

  3. 2. Redox processes and oxidative stress in cell and tissue damage

    Författare :Lisa Arodin Selenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxidative stress is described as an imbalance between oxidants and antioxidants, with a shift towards the oxidants. When the antioxidative systems are insufficient or the production of radicals is increased oxidative damage can occur, damaging DNA, lipids, and proteins. Oxidative stress has been implicated in several pathologies. LÄS MER

  4. 3. Oxidative stress in cell and tissue damage and selenium-based therapeutics in cancer

    Författare :Rim Jawad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Redox homeostasis is the balance between cellular prooxidants and antioxidants, maintained by the interplay of electrons. Reactive oxygen species (ROS) is a term for molecules with unpaired valence electrons or unstable bonds. LÄS MER

  5. 4. Mechanisms of liver allograft rejections

    Författare :Xupeng Ge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver transplantation; acute rejection; antibody; biliary epithelial cell; sinusoidal endothelial cell; cholangitis; toll-like receptor;

    Sammanfattning : Liver transplantation (M) has become a standard treatment for many end-stage liver diseases. However, acute rejections still occur in about half of the liver transplant recipients even treated with a combination of different modem immunosuppressants. LÄS MER

  7. 5. Immune interactions with the liver

    Författare :Azza Karrar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver sinusoid; endothelial cells; apoptosis; antibodies; liver immunity; biliary cells; autoimmune liver diseases; estrogen;

    Sammanfattning : The liver has an important role in the induction of immune tolerance and can be a target for immune mediated damage. The following studies are performed to address the role of liver sinusoidal endothelial cells (LSEC) in tolerance induction and to understand some of the mechanisms involved in the pathogenesis of primary sclerosing cholangitis (PSC). LÄS MER