Sökning: "single-nucleotide polymorphisms"

Visar resultat 6 - 10 av 219 avhandlingar innehållade orden single-nucleotide polymorphisms.

  1. 6. Understanding the adaptive capacity of the bumblebee Bombus terrestris across native and novel environments

    Författare :Cecilia Hjort; Biodiversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bumblebees; Bombus terrestris; Pollination; Introgression; Single nucleotide polymorphisms; Whole Genome Sequencing; Landscape simplification; Gene flow; Morphology; Environmental variation; Invasion; Local adaptation; Island;

    Sammanfattning : Anthropogenic stressors such as agricultural intensification, climate change, andincreased densities of non-native managed bees used for crop pollination arecontributing to bee declines. Understanding how and why bees have responded topast environmental changes is crucial for predicting future ones and enablingmitigation to maintain the functioning of both natural and agricultural ecosystems. LÄS MER

  3. 7. Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course

    Författare :Alf Kastbom; Thomas Skogh; Peter Söderkvist; Alex Karlsson-Parra; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; autoantibodies; single-nucleotide polymorphisms; disease course; Rheumatology; Reumatologi;

    Sammanfattning : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial joints. Although its causes remain largely unknown, a substantial genetic contribution is known to exist. LÄS MER

  4. 8. The impact of gonadotropin receptor polymorphisms on human reproductive function

    Författare :Ida Lindgren; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :FSHR; LHCGR; single-nucleotide polymorphism SNP ; in vitro fertilization IVF ; reproduction; Infertility; male fertility; female fertility;

    Sammanfattning : To date, approximately 15% of all couples worldwide suffer from infertility. The management include controlledovarian hyper-stimulation of the women with follicle-stimulating hormone (FSH) and semen analysis of the men,prior to in vitro fertilization (IVF) and transfer of the fertilized embryo to the uterine cavity. LÄS MER

  5. 9. Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

    Författare :Salma Butt; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subgroups; stage; survival; Breast cancer risk; parity; nulliparity; multiparity; breastfeeding; age at first birth; single nucleotide polymophisms;

    Sammanfattning : The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. LÄS MER

  7. 10. Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development

    Författare :Anna Zettergren; Göteborgs universitet; []
    Nyckelord :Parkinson s disease; genetics; inflammation; single nucleotide polymorphism; dopamine neuron development; estrogen; gene; age of onset; Pitx3; estrogen receptor beta; interleukin 6;

    Sammanfattning : Abstract GENETICS OF PARKINSON’S DISEASE - WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be influenced by genetic factors. In some rare cases of familial PD, mutations in some specific genes are known to cause the disease, but in the more common sporadic form of PD the causes are probably environmental factors interacting with genetic vulnerability. LÄS MER