Sökning: "single-domain"

Visar resultat 21 - 25 av 34 avhandlingar innehållade ordet single-domain.

1. 21. Exploring the Role of the PDZ Domain in a Supramodule

   Författare :Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER

3. 22. High-Tc SQUIDs for biomedical applications: immunoassays, MEG, and ULF-MRI

   Författare :Fredrik Öisjöen; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : This thesis describes high transition temperature superconducting quantum interference devices (high-Tc SQUIDs) for magnetic immunoassays (MIAs), magnetoencephalography (MEG) and ultra-low field magnetic resonance imaging (ULF-MRI).High-Tc dc SQUID sensors were fabricated in single layers of YBa2Cu3O7−δ deposited by pulsed laser deposition and patterned using photolithography on 10×10 mm2 SrTiO3 bicrystal substrates. LÄS MER

4. 23. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

   Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

   Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER

5. 24. Magnetic properties of magnetosomal greigite and factors influencing its occurrence and preservation in Baltic Sea Littorina sediments

   Författare :Maja Reinholdsson; Kvartärgeologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Baltic Sea; deep basins; mineral magnetic properties; magnetotactic bacteria; magnetosomal greigite; laminated sapropels; organic carbon; geochemistry.;

   Sammanfattning : The Baltic Sea is one of the world’s largest brackish water environments and is today suffering from, for example, eutrophication, spreading hypoxia, accumulations of contaminants and invasive organisms. These problems exist due to a combination of natural features that makes the Baltic Sea a sensitive ecosystem (such as long water residence time, limited water exchange, large catchment area), and anthropogenic pressures on land, (such as agriculture and land-use changes, large human populations and industries) and in the sea (such as transport, fishing and bottom-trawling). LÄS MER

7. 25. Bacterial display systems for engineering of affinity proteins

   Författare :Filippa Fleetwood; John Löfblom; Harald Kolmar; KTH; []
   Nyckelord :Combinatorial protein engineering; staphylococcal display; Affibody; biparatopic; VEGFR2; nanobody; E. coli display; autotransporter; Bioteknologi; Biotechnology;

   Sammanfattning : Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. LÄS MER