Sökning: "single molecule microscopy"
Visar resultat 1 - 5 av 70 avhandlingar innehållade orden single molecule microscopy.
1. Single Molecule Detection : Microfluidic Automation and Digital Quantification
Sammanfattning : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. LÄS MER
2. Genotyping and Mutation Detection In Situ : Development and application of single-molecule techniques
Sammanfattning : The human body is composed of trillions of cells closely working together to maintain a functional organism. Every cell is unique in molecular composition and can acquire genetic variations that might cause it to turn pathological. LÄS MER
3. Tracking single molecules in uncharted territory : A single-molecule method to study kinetics in live bacteria
Sammanfattning : The synthesis of proteins, also known as translation, is a fundamental process in every living organism. The steps in the translation of genetic information to functional proteins have been meticulously studied, mostly using in vitro techniques, yielding a detailed model of their mechanisms. LÄS MER
4. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics
Sammanfattning : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. LÄS MER
5. Nanofluidics for Static and Dynamic DNA-Protein Interaction Studies - Repair of Double-Strand Breaks from a Single-Molecule Perspective
Sammanfattning : Double-strand breaks (DSBs) is one of the most lethal forms of DNA damage. A single DSB may result in stalling of vital cellular machineries, and thus, requires immediate measures by the cell. LÄS MER