Sökning: "single gene effect"

Visar resultat 1 - 5 av 295 avhandlingar innehållade orden single gene effect.

1. 1. Quantification of gene expression in single cells

   Författare :Martin Bengtsson; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Biomedical sciences; Biomedicinska vetenskaper; quantitative gene expression analysis; single cell PCR; islets of Langerhans;

   Sammanfattning : Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. LÄS MER

3. 2. Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

   Författare :Tomas Björklund; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; Parkinson’s disease; L-DOPA; dyskinesia; GTP cyclohydrolase 1; tyrosine hydroxylase; dopamine; gene therapy; enzyme replacement; gene regulation; aromatic L-amino acid decarboxylase;

   Sammanfattning : The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. LÄS MER

4. 3. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach

   Författare :Veronica Magnusson; Jerry Lanchbury; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). LÄS MER

5. 4. Development of nonviral gene delivery and of anti-gene reagents

   Författare :Rongbin Ge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Although significant progress has been made in the basic science and applications of various non-viral gene delivery systems, the majority of non-viral approaches are still much less efficient than viral vectors, especially for in vivo gene delivery, Therefore, non-viral gene delivery must be developed in order to increase the efficiency of in vivo delivery. Moreover, a novel anti-gene reagent was developed for sequence-specific gene silencing. LÄS MER

7. 5. Milk Genomics – Impact of Genetic Polymorphism on Bovine Milk Composition and Processability

   Författare :Maria Glantz; Livsmedelsteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; milk genomics; bovine milk; milk composition; technological properties; processability; cheese; quantitative genetic evaluation; single gene effect; genomic selection; genetic polymorphism; leptin; direct genomic value;

   Sammanfattning : Milk genomics is a new area of research that explores the relations between cow genetics and milk characteristics. Identifying the genes controlling compositional and technological traits of milk will give opportunities to select cows for targeted milk production. In this thesis, the impact of different genetic approaches, i.e. LÄS MER