Sökning: "signalosome"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet signalosome.

  1. 1. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

    Författare :Stefan Broselid; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AKAP5; AKAP; MAGUK; cAMP signaling; constitutive signaling; signalosome; GPER; GPR30; GPCR; cytokeratin; RAMP3; apoptotic signaling; breast cancer; PDZ; PDZ-ligand;

    Sammanfattning : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. LÄS MER

  3. 2. Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly

    Författare :Dara Mohammad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse signal transduction pathways. LÄS MER

  4. 3. Role of coxsackie- and adenovirus receptor (CXADR/CAR) in the regulation of cell plasticity in cancer and inflammation

    Författare :Azadeh Nilchian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The coxsackie- and adenovirus receptor (CXADR) is a transmembrane protein, which localizes at tight junctions (TJ) in epithelial cells. As highlighted by its name, CXADR was initially identified as a receptor for type C adenoviruses and group B coxsackieviruses. LÄS MER

  5. 4. A molecular network mediating adventitious root initiation in Arabidopsis thaliana

    Författare :Abdellah Lakehal; Catherine Bellini; Malcolm Bennett; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Adventitious rooting; auxin; jasmonate; cytokinin; phytohormone perception and signalling; vegetative propagation;

    Sammanfattning : To adapt to the ever-changing rhizosphere conditions, land plants evolved a sophisticated root system. The genetic determinants of the root system establishment have been the targets of natural selection, resulting in a very complex but robust molecular networks and circuits. LÄS MER

  7. 5. Na,K-ATPase as signaling transducer

    Författare :Juan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. LÄS MER