Sökning: "signaling pathways"

Visar resultat 1 - 5 av 713 avhandlingar innehållade orden signaling pathways.

  1. 1. Signaling pathways in Drosophila immunity

    Författare :Shiva Seyedoleslami Esfahani; Ylva Engström; Steven Wasserman; Stockholms universitet; []
    Nyckelord :Drosophila immunity; signaling pathways; Cactus; NFκB; Molecular Biology; molekylärbiologi;

    Sammanfattning : Drosophila relies on innate immunity to protect itself from its hostile environment throughout its life cycle. Despite the remarkable progress in understanding many aspects of Drosophila immunity, there are still big gaps in our knowledge. LÄS MER

  3. 2. On boundary value problems for intracellular subdiffusion and signaling pathways, and for geometric flows

    Författare :Tobias Gebäck; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; boundary value problems; diffusion-reaction equations; signaling pathways; anomalous diffusion; pseudo-differential equations; fluorescence correlation spectroscopy; immersed interface method; Boolean grids; mean curvature flow; pseudo-differential equations; boundary value problams; flourescence correlation spectroscopy;

    Sammanfattning : The main part of this thesis concerns mathematical models for diffusion of proteins inside cells, including reactions between the proteins. Initially, such models are applied to describe signaling pathways in yeast cells, and the properties of the model are studied, especially in relation to models that do not include diffusion. LÄS MER

  4. 3. HIF-dependent Signaling Pathways in Cancer

    Författare :Elinn Johansson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Hypoxia; ccRCC; glioma; CD44; Notch1; reactive astrocytes;

    Sammanfattning : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. LÄS MER

  5. 4. Studies on ITK-SYK signaling pathways

    Författare :Alamdar Hussain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chromosomal alterations are frequent causes of cancer. Until now, SYK is reported in two different chromosomal translocation events generating the ITK-SYK-fusion protein in a subset of peripheral T cell lymphomas and the TEL-SYK fusion protein in a case of myelodysplastic syndrome. LÄS MER

  7. 5. Exploring signaling pathways in endothelial mechanotransduction

    Författare :Yumeng Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mechanotransduction, the process by which cells sense and convert mechanical forces from their surroundings, plays a pivotal role in cellular function. For vascular endothelial cells, coping with the continuous and significant shear stress caused by blood flow is essential for the stability of the circulatory system. LÄS MER