Sökning: "signaling effects"

Visar resultat 6 - 10 av 773 avhandlingar innehållade orden signaling effects.

  1. 6. Studies on the transmembrane signaling of β1 integrins

    Författare :Annika Armulik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. LÄS MER

  3. 7. Analysis of PDGF receptor internalization and signaling using proximity ligation assays

    Författare :Marie Rubin Sander; Ola Söderberg; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGFRβ; dynamin; proteolytic cleavage; signaling; internalization; protein-protein interaction; short linear motif; viral hijack; in situ PLA; Molboolean;

    Sammanfattning : Cell signaling is mediated by signaling proteins that relay the signal in an intricate network of interactions before the signal is translated into a biological response. Short linear motifs (SLiMs) in intrinsically disordered regions of proteins serve as docking sites for protein interaction in all aspects of cell regulation including signal transduction. LÄS MER

  4. 8. Lysophosphatidic acid : Physiological effects and structure-activity relationships

    Författare :Ulrika K. Nilsson; Samuel Svensson; Karin E. Bornfeldt; Linköpings universitet; []
    Nyckelord :Lysophospholipids pharmacology; physiology; structure-activity relationship; muscle; smooth; drug effects; myometrium; norepinephrine; epinephrine; signal transduction; MEDICINE; MEDICIN;

    Sammanfattning : Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. LÄS MER

  5. 9. Signaling via Orexin Receptors : A Pharmacological Study

    Författare :Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; Physiology; Fysiologi;

    Sammanfattning : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. LÄS MER

  7. 10. Estrogen signaling in stroke : genetic and experimental studies

    Författare :Magnus Strand; Tommy Olsson; Jan Hillert; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; intracerebral hemorrhage; ischemic stroke; genetics; ERα; OPG; 17β-estradiol; enriched environment; learning and memory; hippocampus; NGFI-A; Medicine; Medicin;

    Sammanfattning : Stroke is a common and multifactorial disease influenced by genetic and environmental risk factors. It is a highly heterogeneous entity consisting of two main types, ischemic (80%) and hemorrhagic (20%) stroke. The most common form of hemorrhagic stroke is intracerebral hemorrhage (ICH). LÄS MER