Sökning: "shotgun assembly"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden shotgun assembly.
1. Software Tools and Algorithms for Shotgun Sequence Assembly
Sammanfattning : During the last ten years, a genomics revolution has changed the ways biological research is carried out. The draft sequence of the human genome is available, as well as the sequence of 84 other completed genomes. LÄS MER
2. Solving repeat problems in shotgun sequencing
Sammanfattning : Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and then sheared in a random fashion. LÄS MER
3. Thermodynamics of Protein Folding and Design
Sammanfattning : The protein folding and protein design problems are addressed, using coarse-grained models with only two types of amino acids, hydrophobic and hydrophilic. In addition to hydrophobicity forces, the models contain sequence-independent local interactions which are found to strongly influence the thermodynamics of these models. LÄS MER
4. Topics in discrete random structures
Sammanfattning : This thesis presents four papers on problems in discrete probability. A common theme of the articles is to take some class of discrete structures, impose some randomness, and then consider what happens asymptotically as the size of the structure tends to infinity. LÄS MER
5. A model for membrane organization and protein sorting in the cyanobacterium Synechocystis sp. PCC 6803
Sammanfattning : Cyanobacteria constitute a unique group of eubacteria, possessing outer and plasma membranes as well as internal thylakoid membranes, the site for both photosynthesis and respiration. The combination of sucrose density centrifugation and two-phase partitioning methods leads to purification of different membranes from the cyanobacterium Synechocystis sp. LÄS MER