Sökning: "short linear motifs"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden short linear motifs.

  1. 1. Diving into short linear motifs : Large-scale identification of endogenous and host-pathogen protein-protein interactions and further characterized by deep mutational scanning

    Författare :Caroline Benz; Ylva Ivarsson; Birthe B. Kragelund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein-protein interactions; short linear motif; endogenous interactions; host-pathogen; viral hijacking; deep mutational scanning; Biokemi; Biochemistry;

    Sammanfattning : Short linear motifs (SLiMs) are protein-protein interaction sites that play an essential role in distinct cellular processes. Those interactions are challenging to capture by common high-throughput methods. LÄS MER

  3. 2. Evolution and viral mimicry of short linear motif-mediated interactions

    Författare :Filip Mihalič; Per Jemth; Leo James; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phage display; protein-protein interactions; large-scale discovery; short linear motifs; viral mimcry; viral hijacking; Biokemi; Biochemistry; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Proteins are one of the most fundamental building blocks of life and their interactions regulate every cellular process. Historically they have been conceptualized as predominantly folded entities with well-defined secondary and tertiary structures. LÄS MER

  4. 3. Identification of SLiMs: Mapping and characterizing motif-based protein interactions

    Författare :Muhammad Ali; Ylva Ivarsson; Shoshana Wodak; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phage display; protein-protein interactions; short linear motifs; PDZ; FERM; affinity; x-ray crystallization; molecular docking; NLS;

    Sammanfattning : During the last twenty years it has become evident that about 35-40% of amino acids in the proteome are in regions that have evolved to remain unstructured. These intrinsically disordered regions contain short linear motifs (SLiMs), which serve as docking sites for protein-protein interactions. LÄS MER

  5. 4. Exploring conditional motif-based protein interactions in health and disease

    Författare :Johanna Kliche; Ylva Ivarsson; Ulrich Stelzl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ProP-PD; protein-protein interaction; short linear motif; phosphorylation; disease mutation; Biokemi; Biochemistry;

    Sammanfattning : Protein-protein interactions (PPIs) orchestrate a variety of cellular events, ranging from signal transduction, scaffolding to subcellular localisation. A subclass of PPIs is mediated by short linear motifs, which are short amino acid stretches found in the intrinsically disordered regions of the proteome. LÄS MER

  7. 5. Exploration of analytical methods to study motif-mediated host-virus protein-protein interactions

    Författare :Eszter Kassa; Ylva Ivarsson; Gilles Travé; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein-protein interaction; short linear motif; affinity purification-mass spectrometry; virus; SARS-CoV-2; TBEV; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : Proteins are responsible for countless processes in living creatures, but most often they do not perform these tasks alone. Rather, they engage in interactions with other proteins, creating whole protein-protein interaction (PPI) networks. LÄS MER