Sökning: "shelterin"

Hittade 4 avhandlingar innehållade ordet shelterin.

  1. 1. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

    Författare :Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

    Sammanfattning : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. LÄS MER

  3. 2. Molecular characterization of the interplay between DNA-PK and TRF2 in telomere protection

    Författare :Beatrice Toia; Francisca Lottersberger; Anita Öst; Grazia Daniela Raffa; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The genetic material of mammalian cells is organized as linear chromosomes inside their nucleus. In order to preserve genomic stability, mammalian cells have developed several mechanisms to detect and repair DNA lesions that can occasionally occur in the genome. LÄS MER

  4. 3. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis

    Författare :Siamak Akbari Kamranvar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV;

    Sammanfattning : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. LÄS MER

  5. 4. Telomerase in hematological and other malignancies : therapeutic implications

    Författare :Bingnan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. LÄS MER